Antioxidant and anti-osteoporotic effects of anthraquinones and related constituents from the aqueous dissolved Aloe exudates

  • Nat Prod Res. 2017 Dec;31(23):2810-2813. doi: 10.1080/14786419.2017.1295238.
Ya Nan Sun  1 ,  Wei Li  2 ,  Sang Hyun Lee  3 ,  Hae Dong Jang  3 ,  Jin Yeul Ma  2 ,  Young Ho Kim  1
Affiliations
  • 1. a College of Pharmacy , Chungnam National University , Daejeon , Korea.
  • 2. b Korean Medicine (KM) Application Center , Korea Institute of Oriental Medicine , Daegu , Korea.
  • 3. c Department of Food and Nutrition , Hannam University , Daejeon , Korea.
PMID: 28287279 DOI: 10.1080/14786419.2017.1295238
Abstract

In this study, 25 known Anthraquinones and related compounds were isolated from aqueous dissolved Aloe exudates. The antioxidant and anti-osteoporotic activities of the isolated compounds were then investigated. Compounds 8, 11, 20, and 23 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays at a concentration of 10.0 μM. Additionally, compounds 7, 9, 15-16, 18, 21-22 and 24-25 showed potent peroxyl radical-scavenging activities with values ranging from 5.28 to 14.60 at 10.0 μM. Moreover, compounds 8, 11, 15, 20 and 22 exhibited significantly suppressed tartrate-resistant Acid Phosphatase (TRAP) activity in nuclear factor-κB ligand-activated osteoclastic RAW 264.7 cells, with values of 125.67, 118.54, 127.64, 125.82 and 124.98%, respectively. These results indicate that Aloe is an excellent source of antioxidant and anti-osteoporotic phytochemicals.

Keywords
Aloe; anthraquinone; anti-osteoporosis; antioxidant; asphodelaceae.
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