Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels

  • Carbohydr Res. 2019 Oct 1;484:107778. doi: 10.1016/j.carres.2019.107778.
Le Duc Dat  1 ,  Nguyen Thi Minh Tu  2 ,  Ngo Viet Duc  3 ,  Bui Thi Thuy Luyen  4 ,  Chu Thi Thanh Huyen  5 ,  Hyun Jae Jang  6 ,  Dang Thi Thu  7 ,  Tran Thu Huong  8 ,  Le Huyen Tram  9 ,  Nguyen Van Thong  10 ,  Nguyen Duc Hung  11 ,  Young Ho Kim  12 ,  Nguyen Phuong Thao  13
Affiliations
  • 1. Division of Computational Physics, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address: [email protected].
  • 2. School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: [email protected].
  • 3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address: [email protected].
  • 4. Hanoi Univerisity of Pharmacy, 13-15, Le Thanh Tong, Hanoi, Viet Nam. Electronic address: [email protected].
  • 5. Hanoi Univerisity of Pharmacy, 13-15, Le Thanh Tong, Hanoi, Viet Nam. Electronic address: [email protected].
  • 6. Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeonbuk, 56212, Republic of Korea. Electronic address: [email protected].
  • 7. School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: [email protected].
  • 8. School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: [email protected].
  • 9. School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: [email protected].
  • 10. School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: [email protected].
  • 11. Centre for Drug Research and Technology Transfer, Phutho College of Medicine and Pharmacy, Viettri City, Phutho Province, Viet Nam.
  • 12. College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. Electronic address: [email protected].
  • 13. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
PMID: 31470215 DOI: 10.1016/j.carres.2019.107778
Abstract

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells.

Keywords
Anti-inflammatory effect; Leguminosae; Mildiside A; Millettia dielsiana; Phenolic compound.
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