Bcl-B: an "unknown" protein of the Bcl-2 family

  • Biol Direct. 2023 Oct 30;18(1):69. doi: 10.1186/s13062-023-00431-4.
N V Pervushin  1  2 ,  G S Kopeina  3  4 ,  B Zhivotovsky  5  6  7
Affiliations
  • 1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
  • 2. Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia.
  • 3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. [email protected].
  • 4. Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. [email protected].
  • 5. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. [email protected].
  • 6. Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. [email protected].
  • 7. Division of Toxicology, Institute of Environmental Medicine, Karolinska Institute, Box 210, Stockholm, 17177, Sweden. [email protected].
PMID: 37899453 DOI: 10.1186/s13062-023-00431-4
Abstract

Bcl-B is a poorly understood protein of the Bcl-2 Family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different Cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.

Keywords
Bcl-2 family proteins; Bcl-B/Bcl-2L10; Carcinogenesis; Embryogenesis; Oogenesis; Programmed cell death.