1. Anti-infection
  2. HIV
  3. Reverse transcriptase-IN-4

Reverse transcriptase-IN-4 

Cat. No.: HY-152233
Handling Instructions

Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC50 value of 0.053 μM for wild-type HIV-1 and an EC50 value of 0.26 μM for HIV-1 mutant E138K.

For research use only. We do not sell to patients.

Reverse transcriptase-IN-4 Chemical Structure

Reverse transcriptase-IN-4 Chemical Structure

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Description

Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC50 value of 0.053 μM for wild-type HIV-1 and an EC50 value of 0.26 μM for HIV-1 mutant E138K[1].

In Vitro

Reverse transcriptase-IN-4 (compound F10) (0-10 μM) shows very weak inhibitory effects on all CYP enzymes, and the inhibitory activities of CYP1A2, CYP2D6, CYP3A4T and CYP3A4M exceeds 50 μM. No significant inhibition is observed for CYP2C9 and CYP2C19, with IC50 values of 35.8 μM and 27.1 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Reverse transcriptase-IN-4 (compound F10) (1.0 g/kg, p.o) is well tolerated in mice, has no acute toxicity and has a good in vivo safety profile[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.45

Formula

C17H21N5OS

SMILES

CC1=CC(C)=CC(C(C2=C(C(NC(SC(C)C)=N2)=O)C)N=[N+]=[N-])=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Reverse transcriptase-IN-4
Cat. No.:
HY-152233
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