1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB 204741

SB 204741 

Cat. No.: HY-103153
Handling Instructions

SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.

For research use only. We do not sell to patients.

SB 204741 Chemical Structure

SB 204741 Chemical Structure

CAS No. : 152239-46-8

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Description

SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1[1].

IC50 & Target[1]

human 5-HT2B Receptor

7.1 (pKi)

In Vitro

The most selective 5-HT2B receptor ligand to be tested is SB 204741 with approximately 20 fold selectivity for the human 5-HT2B receptor as compared to the human 5-HT2C receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB-204741 (0.25~1.0 mg/kg; i.p.) induces myocardial remodeling and dose dependently improves hemodynamic and ventricular functions following isoproterenol-induced myocardial injury[1].
SB-204741 bolsters endogenous anti-oxidant enzymes activities, improves cardiac injury markers, NO level and lipid peroxidation level and attenuates TNFα level in isoproterenol-induced myocardial remodeling in rats. SB-204741 (0.5 and 1.0 mg/kg/day) pre-treatment for 28 days significantly amplifies NO level and GSH and SOD activities and attenuates TBARS level following isoproterenol-induced myocardial remodeling. SB-204741 inhibits inflammatory protein expression, upregulates autophagy and HSPs protein expressions in isoproterenol-induced myocardial remodeling in rats. SB-204741 improves myocardial architecture in isoproterenol-induced myocardial remodeling in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 0.25~1.0 mg/kg
Administration: I.p.
Result: Induced myocardial remodeling.
Molecular Weight

286.35

Formula

C₁₄H₁₄N₄OS

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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SB 204741
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HY-103153
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