Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
Chain terminator
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "Chain terminator" in MCE Product Catalog:
Cat. No.: HY-137697B
CAS No.: 93939-77-6
Research Areas:
ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
Cat. No.: HY-W014282
CAS No.: 599-64-4
Target:
Research Areas:
4-Cumylphenol is a polycarbonate chain terminator. 4-Cumylphenol is widely used as a material for polycarbonate plastics, surfactants, fungicides and preservatives. 4-Cumylphenol also induces lipid accumulation in mouse adipocytes .
Cat. No.: HY-W591476D
CAS No.: 134874-49-0
Synonyms: mPEG350-SH
Cat. No.: HY-W091784R
CAS No.: 10300-27-3
Category:
Cat. No.: HY-171575
CAS No.: 90053-18-2
Target:
Research Areas:
3'-Amino-2',3'-dideoxy-ATP is a modified nucleotide. 3'-Amino-2',3'-dideoxy-ATP can serve as a potent chain terminator for various DNA sequencing methods, including radioactive and fluorescent sequencing, and is compatible with multiple sequencing enzymes .
Cat. No.: HY-171632
CAS No.: 870997-99-2
Research Areas:
2'-(2-Nitrobenzyl)-ATP is an rATP analog. 2'-(2-Nitrobenzyl)-ATP acts as a transcription terminator, inhibiting further RNA chain elongation by T7 RNA polymerase .
Cat. No.: HY-171632A
Research Areas:
2'-(2-Nitrobenzyl)-ATP trisodium is a rATP analog. 2'-(2-Nitrobenzyl)-ATP trisodium acts as a transcription terminator, inhibiting further RNA chain elongation by T7 RNA polymerase .
Cat. No.: HY-171587
CAS No.: 69383-05-7
3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
Cat. No.: HY-10240R
CAS No.: 940908-79-2
Synonyms: RG 7128 (Standard); R-7128 (Standard); PSI 6130 diisobutyrate (Standard)
Target:
Research Areas:
Mericitabine (Standard) is the analytical standard of Mericitabine. This product is intended for research and analytical applications. Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
Cat. No.: HY-134991
CAS No.: 55968-37-1
Synonyms: 3′-Deoxyguanosine 5′-triphosphate
Research Areas:
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM) .
Cat. No.: HY-134991A
Synonyms: 3′-Deoxyguanosine 5′-triphosphate trisodium
Research Areas:
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM) .
Cat. No.: HY-176893
CAS No.: 2410723-30-5
Target:
Research Areas:
Mm-C3-OSu (Methyl Maleate-C3-N-Hydroxysuccinimide Ester) is a structurally defined linker intermediate with a cis-configured methyl maleate (Mm) core and a C3 alkyl chain terminated by an N-hydroxysuccinimide (OSu) reactive group, designed for constructing stable antibody-drug conjugates (ADCs).
Cat. No.: HY-171587A
3′-Deoxy CTP trisodium is the sodium salt form of 3′-Deoxy CTP (HY-171587). 3′-Deoxy CTP trisodium is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP trisodium can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP trisodium can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
Cat. No.: HY-131804A
Synonyms: 3'-O-Ac-dCTP tetrasodium
Research Areas:
3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate (3'-O-Ac-dCTP) tetrasodium is a nucleoside triphosphate derivative with potential applications in DNA synthesis and nucleoside drug design. 3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium can be used to inhibit chain elongation reactions and as a terminator or biochemical probe .
Cat. No.: HY-W101673R
CAS No.: 2416-95-7
Research Areas:
Dipropofol (Standard) is the analytical standard of Dipropofol. This product is intended for research and analytical applications. Dipropofol is a dimeric derivative of Propofol (HY-B0649) with antioxidant and antibacterial activities. Dipropofol terminates free radical chain reactions, scavenges DPPH free radicals and inhibits lipid peroxidation. Dipropofol protects cells from death induced by glutamate, Aβ(25-35) and buthionine sulfoximine, and increases the survival rate of mice exposed to oxygen. Dipropofol selectively activates tonic GABAA currents, hyperpolarizes resting membrane potential, reduces action potential firing, and alleviates the severity of seizures induced by Kainic acid. Dipropofol can be used in the research of Gram-positive bacterial infections, Alzheimer's disease, cerebral ischemia-related neuronal injury, oxygen toxicity and temporal lobe epilepsy .
Cat. No.: HY-16496A
CAS No.: 1060763-87-2
Synonyms: OSI-7836 hydrochloride
Target:
Research Areas:
Thiarabine (OSI-7836) hydrochloride is an orally active cytotoxic antitumor agent that acts as a deoxycytidine kinase substrate and a DNA chain terminator. Thiarabine hydrochloride is metabolized to form its major active metabolite T-araCTP, which potently inhibits DNA synthesis and exhibits a long retention time in tumor cells. Thiarabine hydrochloride is widely applicable to research related to leukemia, lymphoma, hematologic malignancies, acute myeloid leukemia, and advanced solid malignancies .
Cat. No.: HY-137697A
Research Areas:
ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
Cat. No.: HY-177789
Target:
Research Areas:
2',3'-ddT Phosphoramidite is a specially modified nucleotide monomer that is specifically used for solid-phase oligonucleotide synthesis. Once 2',3'-ddT Phosphoramidite is incorporated at the end of a DNA chain, it cannot continue to extend through normal phosphodiester bonds, and thus can also be used as a chain terminator.
Cat. No.: HY-171577
CAS No.: 90053-19-3
Target:
Research Areas:
3′-Amino-2′,3′-dideoxy-GTP is a GTP derivative. 3′-Amino-2′,3′-dideoxy-GTP can act as a chain terminator in DNA synthesis .
Cat. No.: HY-171576
CAS No.: 90053-16-0
Target:
Research Areas:
3'-Amino-2',3'-dideoxy-TTP is a thymidine triphosphate (TTP) derivative. 3'-Amino-2',3'-dideoxy-TTP can act as a chain terminator in DNA synthesis .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
