55968-37-1
55968-37-1
Chemical Structure
3'-Deoxy-GTP
Synonym(s): 3′-Deoxyguanosine 5′-triphosphate
- CAS No.: 55968-37-1
- Formula:C10H16N5O13P3
- Molecular Weight:507.18
IUPAC Name: ((2S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: QGYIFQKZZSSUCR-OBXARNEKSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)C[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3)C=N2)NC(N)=N1
Biological Activity: 3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM)[1][2].
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3'-Deoxy-GTP | 3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM). | |||||||||||||||||||||
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References
- [1]. Yin Z, et al. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. [Content Brief]
- [2]. Oliveira AF, et al. Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses. Molecules. 2017 Mar 22;22(3):505. [Content Brief]
Keywords
