Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

  • Molecules. 2017 Mar 22;22(3):505. doi: 10.3390/molecules22030505.
Ana Flávia Costa da Silveira Oliveira  1  2 ,  Róbson Ricardo Teixeira  3 ,  André Silva de Oliveira  4  5 ,  Ana Paula Martins de Souza  6 ,  Milene Lopes da Silva  7 ,  Sérgio Oliveira de Paula  8
Affiliations
  • 1. Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
  • 2. Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil. [email protected].
  • 3. Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
  • 4. Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
  • 5. Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil. [email protected].
  • 6. Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
  • 7. Departamento de Química, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
  • 8. Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, S/N, 36570-900 Viçosa, MG, Brazil. [email protected].
PMID: 28327521 DOI: 10.3390/molecules22030505
Abstract

Dengue Virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of Infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find Antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target Enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the Enzymes involved in the replication of these viruses.

Keywords
antiviral; chikungunya; dengue; natural products; virus enzymes.
Products