4-Cumylphenol
Based on 1 Customer Validation
4-Cumylphenol is a polycarbonate chain terminator. 4-Cumylphenol is widely used as a material for polycarbonate plastics, surfactants, fungicides and preservatives. 4-Cumylphenol also induces lipid accumulation in mouse adipocytes.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 599-64-4
- Formula: C15H16O
- Molecular Weight:212.29
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
4.4 μM
Compound: 15
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Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
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[PMID: 31980362] |
| HEK293 | IC50 |
13 μM
Compound: 15
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Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
|
[PMID: 31980362] |
| HEK293 | IC50 |
24 μM
Compound: 15
|
Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
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[PMID: 31980362] |
| MCF7 | EC50 |
38 nM
Compound: 15
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Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay
Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay
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[PMID: 23214428] |
4-Cumylphenol (1, 5, 10, 20, 40 µM; 6 days) increase lipid accumulation in 3 T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3 T3-L1 cells
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Concentration:1, 5, 10, 20, 40 µM
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Incubation Time:6 days
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Result:Increase lipid accumulation, which peaked at10 μM with a 204% increase.
Chemical Information
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CAS No. 599-64-4
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Appearance Solid
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Molecular Weight 212.29
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Formula C15H16O
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Color White to off-white
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SMILES
CC(C1=CC=CC=C1)(C2=CC=C(O)C=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (471.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Yue W, et al. Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600. J Hazard Mater. 2021 Aug 15;416:125775. [Content Brief]
[2]. Chiha M, et al. Sonolytic degradation of endocrine disrupting chemical 4-cumylphenol in water. Ultrason Sonochem. 2011 Sep;18(5):943-50. [Content Brief]
[3]. Ramskov Tetzlaff CN, Svingen T, et al. Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A. Environ Toxicol. 2020 May;35(5):543-552. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7105 mL | 23.5527 mL | 47.1054 mL | 117.7634 mL |
| 5 mM | 0.9421 mL | 4.7105 mL | 9.4211 mL | 23.5527 mL | |
| 10 mM | 0.4711 mL | 2.3553 mL | 4.7105 mL | 11.7763 mL | |
| 15 mM | 0.3140 mL | 1.5702 mL | 3.1404 mL | 7.8509 mL | |
| 20 mM | 0.2355 mL | 1.1776 mL | 2.3553 mL | 5.8882 mL | |
| 25 mM | 0.1884 mL | 0.9421 mL | 1.8842 mL | 4.7105 mL | |
| 30 mM | 0.1570 mL | 0.7851 mL | 1.5702 mL | 3.9254 mL | |
| 40 mM | 0.1178 mL | 0.5888 mL | 1.1776 mL | 2.9441 mL | |
| 50 mM | 0.0942 mL | 0.4711 mL | 0.9421 mL | 2.3553 mL | |
| 60 mM | 0.0785 mL | 0.3925 mL | 0.7851 mL | 1.9627 mL | |
| 80 mM | 0.0589 mL | 0.2944 mL | 0.5888 mL | 1.4720 mL | |
| 100 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1776 mL |
4-Cumylphenol Related Classifications
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