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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
74 Results for "
depolymerization
" in MedChemExpress (MCE) Product Catalog:
Products (74)
74 Results for "depolymerization" in MCE Product Catalog:
Art. -Nr.: HY-116920A
CAS. Nr.: 167963-06-6
Forschungsgebiete:
(R)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .
Art. -Nr.: HY-116920B
CAS. Nr.: 167963-04-4
Forschungsgebiete:
(S)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .
Art. -Nr.: HY-145616
CAS. Nr.: 1234218-62-2
Target:
Forschungsgebiete:
Sudocetaxel is a microtubule depolymerization inhibitor for pH-sensitive docetaxel delivery.
Art. -Nr.: HY-124624
CAS. Nr.: 354759-10-7
Target:
Forschungsgebiete:
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells .
Art. -Nr.: HY-117473
CAS. Nr.: 1504583-00-9
Target:
Forschungsgebiete:
DAT-230 is a microtubule inhibitor. DAT-230 induces cell apoptosis and results in microtubule de-polymerization and G2/M phase arrest. DAT-230 inhibits cell growth in vitro and in vivo .
Art. -Nr.: HY-146362
CAS. Nr.: 2454175-89-2
Target:
Forschungsgebiete:
Tubulin polymerization-IN-17 (compound 23g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-17 exhibits tubulin depolymerization and induced cell apoptosis and inhibits migration. Tubulin polymerization-IN-17 has the potential for the research of cancer diseases .
Art. -Nr.: HY-151189
CAS. Nr.: 2488395-07-7
ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability. ROCK-IN-4 reversibly depolymerizes F-actin, and suppresses mitochondrial respiration in human trabecular meshwork (HTM) cells. ROCK-IN-4 can be used for glaucoma or ocular hypertension research .
Art. -Nr.: HY-135746R
CAS. Nr.: 220246-81-1
Forschungsgebiete:
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
Art. -Nr.: HY-N0227R
CAS. Nr.: 105454-04-4
Synonyms: 7-epi-Paclitaxel (Standard)
Art. -Nr.: HY-16146
CAS. Nr.: 288847-34-7
Synonyms: OXi-4503 tetrasodium
Target:
Forschungsgebiete:
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a proagent of Combretastatin A-1, is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 phosphate tetrasodium inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 phosphate tetrasodium exhibits anti-tumor and anti-vascular effects .
Art. -Nr.: HY-121993R
CAS. Nr.: 109971-63-3
Forschungsgebiete:
Combretastatin A-1 (Standard) is the analytical standard of Combretastatin A-1. This product is intended for research and analytical applications. Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects .
Art. -Nr.: HY-B0011AR
CAS. Nr.: 148408-66-6
Synonyms: RP-56976 Trihydrate (Standard)
Forschungsgebiete:
Docetaxel (Trihydrate) (Standard) is the analytical standard of Docetaxel (Trihydrate). This product is intended for research and analytical applications. Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC50 value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .
Art. -Nr.: HY-N0060AR
CAS. Nr.: 24276-84-4
Synonyms: Coniferic acid sodium (Standard)
Art. -Nr.: HY-N1391R
CAS. Nr.: 78432-77-6
Synonyms: 10-Deacetylpaclitaxel (Standard)
Art. -Nr.: HY-W002112R
CAS. Nr.: 5746-86-1
Synonyms: Nornicotine (Standard)
Art. -Nr.: HY-W002112S1
Synonyms: Nornicotine-d7
Art. -Nr.: HY-400684
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995). Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC .
Art. -Nr.: HY-W854934
CAS. Nr.: 114231-14-0
Target:
Forschungsgebiete:
IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM). IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma .
Art. -Nr.: HY-181428
CAS. Nr.: 3061439-13-9
Target:
Forschungsgebiete:
Fmoc-Gly-Gly-Phe-Gly-Docetaxel (compound 16h-3) is a drug-linker conjugate for ADC, which comprises a microtubule depolymerization inhibitor and a linker. Puxitatug samrotecan drug-linker can be used to synthesize antibody-drug conjugate (ADC) .
Art. -Nr.: HY-N18121
CAS. Nr.: 18530-09-1
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
