114231-14-0
Chemical Structure
IKP-104
- CAS. Nr.: 114231-14-0
- Formula:C26H21ClFNO3
- Molecular Weight:449.90
InChIKey: MYSNSNGSKLLDBP-UHFFFAOYSA-N
SMILES: O=C1C(C)=C(C2=CC=C(F)C=C2)N(C3=CC(OC)=CC(OC)=C3Cl)C(C4=CC=CC=C4)=C1
Biological Activity: IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM). IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma[1][2][3][4].
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IKP-104 | IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM). IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma. | |||||||||||||||||||||
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References
- [1]. Khan IA, et al. Differential interaction of tubulin isotypes with the antimitotic compound IKP-104. Biochemistry. 2000 Aug 1;39(30):9001-9. [Content Brief]
- [2]. Mizuhashi F, et al. Antitumor activities of IKP-104, a 4(1H)-pyrizinone derivative, on cultured and implanted tumors. Jpn J Cancer Res. 1990 Dec;81(12):1300-6. [Content Brief]
- [3]. Mizuhashi F, et al. Effects of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, on cytoskeletal microtubules of cultured tumor cells. Jpn J Cancer Res. 1991 Dec;82(12):1442-7. [Content Brief]
- [4]. Mizuhashi F, et al. Interaction of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, with microtubule proteins. Jpn J Cancer Res. 1992 Feb;83(2):211-8. [Content Brief]
