1504583-00-9
1504583-00-9
Chemical Structure
DAT-230
- CAS No.: 1504583-00-9
- Formula:C20H21NO2S
- Molecular Weight:339.45
IUPAC Name: 2-methoxy-5-(2-(3-methoxy-4,5-dimethylphenyl)thiophen-3-yl)aniline
InChIKey: NPXKFXXMFDKVTM-UHFFFAOYSA-N
SMILES: NC1=CC(C2=C(C3=CC(C)=C(C)C(OC)=C3)SC=C2)=CC=C1OC
Biological Activity: DAT-230 is a microtubule inhibitor. DAT-230 induces cell apoptosis and results in microtubule de-polymerization and G2/M phase arrest. DAT-230 inhibits cell growth in vitro and in vivo[1][2].
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DAT-230 | DAT-230 is a microtubule inhibitor. DAT-230 induces cell apoptosis and results in microtubule de-polymerization and G2/M phase arrest. DAT-230 inhibits cell growth in vitro and in vivo. | |||||||||||||||||||||
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References
- [1]. Qiao F, et al. DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells. Biol Pharm Bull. 2013;36(2):193-201. [Content Brief]
- [2]. Tang J, et al. Application of an ultra-performance liquid chromatography method with tandem mass spectrometry to pharmacokinetics, tissue distribution and excretion in the study of DAT-230, a novel tubulin-binding agent candidate, in rats. J Pharm Biomed Anal. 2015;110:49-57. [Content Brief]
Keywords
