78432-77-6
Chemical Structure
10-Deacetyltaxol
Synonym(s): 10-Deacetylpaclitaxel
- CAS No.: 78432-77-6
- Formula:C45H49NO13
- Molecular Weight:811.87
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
InChIKey: TYLVGQKNNUHXIP-MHHARFCSSA-N
SMILES: CC(O[C@]12[C@@]([C@]3([C@@H](O)C[C@@]1([H])OC2)C)([H])[C@@H]([C@]4(C(C)(C([C@@H](O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C4)C)O)OC(C7=CC=CC=C7)=O)=O
Biological Activity: 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative found in Taxus wallichiana Zucc. and exhibits cytotoxicity against human neurotumor cell lines. It shows a concentration-dependent cytotoxic effect on cancer cells and demonstrates activity in the mouse leukemia system. 10-Deacetyltaxol can be used for research on neuroblastoma, glioblastoma multiforme, and lymphocytic leukemia[1][2][3].
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10-Deacetyltaxol | 99.24% | 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative found in Taxus wallichiana Zucc. and exhibits cytotoxicity against human neurotumor cell lines. It shows a concentration-dependent cytotoxic effect on cancer cells and demonstrates activity in the mouse leukemia system. 10-Deacetyltaxol can be used for research on neuroblastoma, glioblastoma multiforme, and lymphocytic leukemia. | ||||||||||||||||||||
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10-Deacetyltaxol (Standard) | ≥98% | 10-Deacetyltaxol (Standard) (10-Deacetylpaclitaxel (Standard)) is the analytical standard of 10-Deacetyltaxol (HY-N1391). This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative found in Taxus wallichiana Zucc. and exhibits cytotoxicity against human neurotumor cell lines. It shows a concentration-dependent cytotoxic effect on cancer cells and demonstrates activity in the mouse leukemia system. 10-Deacetyltaxol can be used for research on neuroblastoma, glioblastoma multiforme, and lymphocytic leukemia. | ||||||||||||||||||||
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References
- [1]. Cheng HL, et al. Cloning and characterization of the glycoside hydrolases that remove xylosyl groups from 7-β-xylosyl-10-deacetyltaxol and its analogues. Molecular & cellular proteomics : MCP. 2013 Aug;12(8):2236-48.
- [2]. Helson L, et al. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. International journal of oncology. 1993 Feb;2(2):297-9. [Content Brief]
- [3]. McLaughlin JL, et al. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9. [Content Brief]
