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2 Results for "
12(R)-HEPE
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "12(R)-HEPE" in MCE Product Catalog:
Cat. No.: HY-117044
CAS No.: 109430-12-8
Target:
Research Areas:
12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus.1 The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE.
Cat. No.: HY-117044A
CAS No.: 81187-21-5
Target:
Research Areas:
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM).
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