Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
1401032-35-6
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "1401032-35-6" in MCE Product Catalog:
Cat. No.: HY-186251
CAS No.: 1401032-35-6
C18-Pyr-Cer is a chemically modified synthetic ceramide analog. C18-Pyr-Cer directly interacts with MAP1LC3B-II. C18-Pyr-Cer induces autophagy, targets autolysosomes to mitochondria, and mediates lethal autophagy in cancer cells. C18-Pyr-Cer can be used in the research of head and neck squamous cell carcinoma .
Cat. No.: HY-176568
Research Areas:
LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
