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1566586-52-4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "1566586-52-4" in MCE Product Catalog:

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Pseudouridimycin
Pseudouridimycin
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Cat. No.: HY-125650
CAS No.: 1566586-52-4
Purity:  ≥96.0%
Synonyms: PUM
Category:  

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:  

Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .
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