1 Result for "

190324-47-1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "190324-47-1" in MCE Product Catalog:

2
Pleurocidin
Pleurocidin
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2 Cited Publications
Cat. No.: HY-P5641
CAS No.: 190324-47-1
Target:  

Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic

Research Areas:  

Infection Inflammation/Immunology

Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .
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