1 Result for "

2227316-74-5

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "2227316-74-5" in MCE Product Catalog:

Cat. No.: HY-149054
CAS No.: 2227316-74-5
Purity:  99.74%
Target:  

GSK-3 Tau Protein AAK1 Pim PKC

Research Areas:  

Neurological Disease

GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease .
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