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2290527-07-8

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1 Results for "2290527-07-8" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-126020
CAS No.: 2290527-07-8
Purity:  99.90%
Target:  

DNA/RNA Synthesis RAD51

Research Areas:  

Cancer

Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .
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