1 Result for "

2379572-34-4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2379572-34-4" in MCE Product Catalog:

Cat. No.: HY-146237
CAS No.: 2379572-34-4
Purity:  98.04%
Synonyms: CC-99282
Research Areas:  

Cancer

Golcadomide (CC-99282) is a blood-brain barrier-permeable, orally active Cereblon (CRBN) E3 ligase modulator. Golcadomide induces Cereblon to form a closed active conformation, thereby recruiting and triggering the ubiquitin-mediated proteasomal degradation of transcription factors IKZF1, IKZF3, Ikaros and Aiolos. Golcadomide is applicable to research related to relapsed or refractory non-Hodgkin lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and diffuse large B-cell lymphoma .
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