1 Result for "

2836273-61-9

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2836273-61-9" in MCE Product Catalog:

Cat. No.: HY-161173
CAS No.: 2836273-61-9
Target:  

PROTACs SOS1 Ras

Research Areas:  

Cancer

PROTAC SOS1 degrader-5 is a potent SOS1 PROTAC degrader with a DC50 value of 13 nM. PROTAC SOS1 degrader-5 induces CRBN-dependent ubiquitination and degradation of SOS1 protein, inhibits the proliferation of KRAS G12C-mutated cancer cells, and suppresses tumor growth in xenograft models. PROTAC SOS1 degrader-5 can be used in studies related to KRAS G12C-mutated non-small cell lung cancer .
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