1 Result for "

2922920-71-4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2922920-71-4" in MCE Product Catalog:

Cat. No.: HY-149916
CAS No.: 2922920-71-4
Target:  

Adenosine Receptor

Research Areas:  

Cancer

A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2) .
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