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3 fucose

" in MedChemExpress (MCE) Product Catalog:

67

Inhibitors & Agonists

1

Fluorescent Dyes

12

Biochemical Assay Reagents

15

Inhibitory Antibodies

10

Natural
Products

4

Recombinant Proteins

4

Isotope-Labeled Compounds

1

Antibodies

4

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116705
    2-Deoxy-2-fluoro-L-fucose
    1 Publications Verification

    		 Glycosyltransferase Cancer
    2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma .
    2-Deoxy-2-fluoro-L-fucose
  • HY-N1480
    (-)-Fucose

    6-Desoxygalactose; L-(-)-fucose; L-Galactomethylose

    		 Endogenous Metabolite Parasite Infection Metabolic Disease Cancer
    (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth .
    (-)-Fucose
  • HY-W096600
    2F-Peracetyl-Fucose
    3 Publications Verification

    1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos

    		 Glycosyltransferase Cancer
    2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) acts as a potent fucosyltransferase (FUT) inhibitor .
    2F-Peracetyl-Fucose
  • HY-134433
    GDP-L-fucose

    		Endogenous Metabolite Metabolic Disease
    GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway. GDP-L-fucose is associated with diabetes in rats .
    GDP-L-fucose
  • HY-P99113A
    Inebilizumab (FUT8-KO)

    		CD19 Inflammation/Immunology
    Inebilizumab (FUT8-KO) is an anti-CD19 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody.Inebilizumab (FUT8-KO) exhibits enhanced ADCC against B cells and can be used for research on multiple sclerosis and neuromyelitis optica .
    Inebilizumab (FUT8-KO)
  • HY-N5102
    D-(+)-Fucose

    		Others Others
    D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon. D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .
    D-(+)-Fucose
  • HY-132177B
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium

    		Glycosidase Metabolic Disease
    α1-2,4,6 Fucosidase O (EC 3.2.1.51) is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal α1-2, α1-4 and α1-6 linked fucose residues from oligosaccharides, with α1-6 fucose residues more efficiently .
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium
  • HY-P99010A
    Bemarituzumab (FUT8-KO)

    		Interleukin Related FGFR Cancer
    Bemarituzumab (FUT8-KO) is an anti-FGFR2b monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Bemarituzumab (FUT8-KO) lacks a core fucose in the polysaccharide portion of the Fc domain of the antibody, and results in a high affinity to human FcγRIIIa .
    Bemarituzumab (FUT8-KO)
  • HY-115495
    6-Alkynyl fucose

    		Biochemical Assay Reagents Others
    6-Alkynyl fucose is a tool in the study of protein O-fucosylation . 6-Alkynyl fucose is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    6-Alkynyl fucose
  • HY-132177C
    α1-3,4 Fucosidase, Bifidobacterium bifidum

    		Glycosidase Metabolic Disease
    α1-3,4 Fucosidase, Bifidobacterium bifidum is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing α1-3 and α1-4 linked fucose residues from oligosaccharides and glycoproteins .
    α1-3,4 Fucosidase, Bifidobacterium bifidum
  • HY-E70555
    PNGase A

    		Glycosidase Others
    PNGase A is a β-aspartylglucosaminidase and N-glycan-releasing enzyme. PNGase A catalyzes hydrolysis reactions to release the N-glycan moiety from glycoproteins or glycopeptides. PNGase A releases N-linked oligosaccharides containing core α-1,3 fucose from glycopeptides. PNGase A undergoes self-deglycosylation, which may cause contamination of endogenous glycan structures in N-glycan analysis. PNGase A cannot be heterologously expressed in recombinant expression systems; it can be extracted and purified from almond seeds .
    PNGase A
  • HY-N7389A
    GDP-D-mannose disodium

    		Endogenous Metabolite Drug Intermediate Metabolic Disease
    GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a Ki value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a Ki value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG) .
    GDP-D-mannose disodium
  • HY-P9977A
    Amivantamab (FUT8-KO)

    		EGFR Cancer
    Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
    Amivantamab (FUT8-KO)
  • HY-P99653A
    Ianalumab (FUT8-KO)

    VAY-736 (FUT8-KO)

    		 TNF Receptor Apoptosis NF-κB Inflammation/Immunology Cancer
    Ianalumab (VAY-736) (FUT8-KO) is an anti-BAFF-R monoclonal antibody expressed in CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose depletion enhances its B cell clearance capacity. Ianalumab (FUT8-KO) competitively blocks the binding of BAFF to BAFF-R, inhibits the BAFF-mediated alternative NF-κB pro-survival signaling pathway, and abrogates the apoptotic (apoptosis) protective effect of BAFF on cancer cells. Ianalumab (FUT8-KO) can be used in research related to primary Sjögren's syndrome and chronic lymphocytic leukemia .
    Ianalumab (FUT8-KO)
  • HY-132177A
    α-1-2 Fucosidase, bifidobacterium longum

    		Glycosidase Metabolic Disease
    α1-2 Fucosidase (EC 3.2.1.51) is a highly specific exoglycosidase that catalyzes the hydrolysis of linear α1-2 linked fucose residues from oligosaccharides .
    α-1-2 Fucosidase, bifidobacterium longum
  • HY-E70029
    α-1,6-Fucosidase, lactobacillus casei

    		Others Others
    alpha-1,6-Fucosidase (LpAlfC(E274A)) (EC 3.2.1.51) cleaves branched non-reducing terminal fucose, linked α(1-6) to the core N-acetylglucosamine of N-linked oligosaccharides. alpha-1,6-Fucosidase (LpAlfC(E274A)) is useful for determining core fucosylation .
    α-1,6-Fucosidase, lactobacillus casei
  • HY-134433A
    GDP-L-fucose disodium

    		Endogenous Metabolite Metabolic Disease
    GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .
    GDP-L-fucose disodium
  • HY-NP0190
    Ulex Europaeus Agglutinin I (Biotinylated)

    UEA I (Biotinylated)

    		 Fluorescent Dye Others
    Ulex Europaeus Agglutinin I Biotinylated (UEA I Biotinylated) is a biotinylated lectin that binds to α1,2-fucosylated proteins and cell-surface glycoconjugates containing α-L-fucose. Ulex Europaeus Agglutinin I Biotinylated serves as a histochemical marker for endothelial cells .
    Ulex Europaeus Agglutinin I (Biotinylated)
  • HY-P9980A
    Belantamab (FUT8-KO)

    		ADC Antibody TNF Receptor Cancer
    Belantamab (FUT8-KO) is an anti-BCMA (TNFRSF17) monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Belantamab (FUT8-KO) can be used to synthesize antibody-active molecule conjugate (ADC), Belantamab mafodotin .
    Belantamab (FUT8-KO)
  • HY-E70026
    L-fucokinase/GDP-fucose pyrophos-phorylase (FKP)

    		Biochemical Assay Reagents Others
    L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) is an enzyme that catalyzes the chemical reaction. L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) has substrate of L-fucose. L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) induces L-fucose phosphorylation to form L-fucose-L-phosphate .
    L-fucokinase/GDP-fucose pyrophos-phorylase (FKP)
  • HY-E70058
    α-1-3,4 Fucosyltransferase, helicobacter pylori

    α-1-3,4 FucT; Hp3/4FT

    		 Endogenous Metabolite Metabolic Disease
    alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (EC 2.4.1.65) (Hp3/4FT) can be found in Helicobacter pylori. alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) catalyzes fucose transfer from donor GDP-beta-l-fucose to the GlcNAc .
    α-1-3,4 Fucosyltransferase, helicobacter pylori
  • HY-160258
    GDP-Fucose-Tz

    GDP-fucose-Am-Tz

    		 Biochemical Assay Reagents Others
    GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a non-natural GDP-fucose analog bearing a Tetrazine group. As a precursor, GDP-Fucose-Tz enables the synthesis of GDP-fucose-ssDNA probes via inverse electron demand Diels-Alder reaction. GDP-Fucose-Tz participates in chemoenzymatic reactions to prepare GDP-fucose-Herceptin derivatives through conjugation with TCO-Herceptin .
    GDP-Fucose-Tz
  • HY-E70064A
    Helicobacter pylori alpha-1,3-fucosyltransferase

    Hp3FT

    		 Glycosyltransferase Others
    Helicobacter pylori alpha-1,3-fucosyltransferase (Hp3FT) catalyzes the glycosyl addition of fucose from the donor GDP-fucose to the acceptor N-acetyllactosamine .
    Helicobacter pylori alpha-1,3-fucosyltransferase
  • HY-E70157
    Fucosyltransferase 8
    1 Publications Verification

    EC:2.4.1.68; FUT8; α1-6FucT

    		 Glucosylceramide Synthase (GCS) Infection
    Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans .
    Fucosyltransferase 8
  • HY-132177H
    exo-α-Fucosidase, Bacteroides fragilis

    		Biochemical Assay Reagents Others
    exo-α-Fucosidase, Bacteroides fragilis (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .
    exo-α-Fucosidase, Bacteroides fragilis
  • HY-W145682
    Blood group H disaccharide

    Blood Group H

    		 Biochemical Assay Reagents Others
    Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes.
    Blood group H disaccharide
  • HY-164169
    GDP-azido-fucose

    		Biochemical Assay Reagents Others
    GDP-Azido-Fucose is a chemically modified donor substrate. GDP-Azido-Fucose can be used to synthesize fluorophore-conjugated GDP-fucose. GDP-Azido-Fucose can be used to study glycosyltransferase reactions .
    GDP-azido-fucose
  • HY-N1480R
    (-)-Fucose (Standard)

    6-Desoxygalactose (Standard); L-(-)-fucose (Standard); L-Galactomethylose (Standard)

    		 Reference Standards Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose (Standard) is the analytical standard of (-)-Fucose. This product is intended for research and analytical applications. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth .
    (-)-Fucose (Standard)
  • HY-N1480S1
    (-)-Fucose-13C-1

    6-Desoxygalactose-13C-1; L-(-)-fucose-13C-1; L-Galactomethylose-13C-1

    		 Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-1
  • HY-180476
    L-Galactose-azide

    		Biochemical Assay Reagents Others
    L-Galactose-azide (compound 1b) is an L-fucose analogue synthesized from L-galactose .
    L-Galactose-azide
  • HY-132177E
    exo-α-Fucosidase, Elizabethkingia meningoseptica

    		Biochemical Assay Reagents Others
    exo-α-Fucosidase, Elizabethkingia meningoseptica (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .
    exo-α-Fucosidase, Elizabethkingia meningoseptica
  • HY-132177D
    exo-α-Fucosidase, Emticicia oligotrophica

    		Biochemical Assay Reagents Others
    exo-α-Fucosidase, Emticicia oligotrophica (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .
    exo-α-Fucosidase, Emticicia oligotrophica
  • HY-132177I
    exo-α-1,2-Fucosidase, Bifidobacterium bifidum

    		Biochemical Assay Reagents Others
    exo-α-1,2-Fucosidase,Bifidobacterium bifidum is a glycoside hydrolase that would release free fucose .
    exo-α-1,2-Fucosidase, Bifidobacterium bifidum
  • HY-E70064
    alpha-1,3-Fucosyltransferase (α1,3FucT)
    1 Publications Verification

    		 Endogenous Metabolite Others
    alpha-1,3-Fucosyltransferase (α1,3FucT) catalyzes the transfer of L-fucose moiety from guanosine diphosphate-beta-L-fucose (GDP-Fuc) to acceptor sugars. alpha-1,3-Fucosyltransferase (α1,3FucT) is often used in biochemical studies, and it can be used to form fucoglycoconjugates .
    alpha-1,3-Fucosyltransferase (α1,3FucT)
  • HY-E70880
    Endoglycosidase CC (N180H mutant)

    EndoCC N180H

    		 Glycosidase Others
    Endoglycosidase CC (N180H mutant) (EndoCC N180H) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc .
    Endoglycosidase CC (N180H mutant)
  • HY-E70881
    Endoglycosidase F3 (D165A mutant)

    EndoF3 D165A

    		 Glycosidase Others
    Endoglycosidase F3 (D165A mutant) (EndoF3 D165A) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc .
    Endoglycosidase F3 (D165A mutant)
  • HY-E70159
    Fucosyltransferase 11

    EC:2.4.1.-; FUT11

    		 Glycosyltransferase Cancer
    Fucosyltransferase 11 (EC:2.4.1.-, FUT11) links alpha-l-fucose onto conalbumin glycopeptides and biantennary N-glycan acceptors. Fucosyltransferase 11 plays an important role in cancer .
    Fucosyltransferase 11
  • HY-N7389B
    GDP-α-D-mannose disodium

    		Endogenous Metabolite Metabolic Disease
    GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
    GDP-α-D-mannose disodium
  • HY-177787A
    2'-Deoxy-N-methyl-AMP ammonium

    		Nucleoside Antimetabolite/Analog Others
    2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation .
    2'-Deoxy-N-methyl-AMP ammonium
  • HY-N5102R
    D-(+)-Fucose (Standard)

    		Reference Standards Others Others
    D-(+)-Fucose (Standard) is the analytical standard of D-(+)-Fucose. This product is intended for research and analytical applications. D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon . D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .
    D-(+)-Fucose (Standard)
  • HY-N1480S
    (-)-Fucose-13C

    6-Desoxygalactose-13C; L-(-)-fucose-13C; L-Galactomethylose-13C

    		 Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti
    (-)-Fucose-13C
  • HY-N1480S3
    (-)-Fucose-13C-3

    6-Desoxygalactose-13C-3; L-(-)-fucose-13C-3; L-Galactomethylose-13C-3

    		 Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-3
  • HY-N1480S2
    (-)-Fucose-13C-2

    6-Desoxygalactose-13C-2; L-(-)-fucose-13C-2; L-Galactomethylose-13C-2

    		 Isotope-Labeled Compounds Endogenous Metabolite Parasite Infection Metabolic Disease
    (-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-2
  • HY-D2278
    GDP-Fucose-Cy5

    		Fluorescent Dye Others
    GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .
    GDP-Fucose-Cy5
  • HY-E70160
    Protein O-Fucosyltransferase 1

    EC:2.4.1.221; POFUT1

    		 Glycosyltransferase Others
    Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a Glycosyltransferase containing the cysteine-rich motifs as the acceptor sugar and GDP-fucose as the donor .
    Protein O-Fucosyltransferase 1
  • HY-NP090A
    Ulex Europaeus Agglutinin I (peroxidase)

    UEA I (peroxidase)

    		 Biochemical Assay Reagents Others
    Ulex Europaeus Agglutinin I (peroxidase) (UEA I (peroxidase)) has anti-H blood group specificity. Ulex Europaeus Agglutinin I (peroxidase) has an affinity for L-fucose .
    Ulex Europaeus Agglutinin I (peroxidase)
  • HY-E70158
    Fucosyltransferase 9

    EC:2.4.1.152; FUT9

    		 Drug Intermediate Others
    Fucosyltransferase 9 (EC:2.4.1.152, FUT9) catalyzes the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. Fucosyltransferase 9 synthesizes the LeX oligosaccharide (CD15) .
    Fucosyltransferase 9
  • HY-E70887
    Broad-specificity fucosidase O

    FucO

    		 Glycosidase Others
    Broad-specificity fucosidase O (FucO) is a α-fucosidase that can efficiently remove α1-6- and α1-3-linked core fucose from N-glycans .
    Broad-specificity fucosidase O
  • HY-P9991A
    Osemitamab (FUT8-KO)

    		Gap Junction Protein Cancer
    Osemitamab (FUT8-KO) is an anti-claudin-18.2 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .
    Osemitamab (FUT8-KO)
  • HY-164169A
    GDP-azido-fucose disodium

    		Biochemical Assay Reagents Others
    GDP-Azido-Fucose disodium is a chemically modified donor substrate. GDP-Azido-Fucose disodium can be used to synthesize fluorophore-conjugated GDP-fucose. GDP-Azido-Fucose can be used to study glycosyltransferase reactions .
    GDP-azido-fucose disodium

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