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3-Methylxanthine (Standard)

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3-Methylxanthine (Standard)
3-Methylxanthine (Standard)
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Cat. No.: HY-50723R
CAS No.: 1076-22-8
Category:  

Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Reference Standards Endogenous Metabolite Phosphodiesterase (PDE) Caspase Bcl-2 Family Apoptosis

3-Methylxanthine (Standard) is the analytical standard of 3-Methylxanthine. This product is intended for research and analytical applications. 3-Methylxanthine is a blood-brain barrier-permeable cyclic GMP phosphodiesterase inhibitor, with an IC50 of 920 μM against guinea pig cyclic GMP phosphodiesterase. 3-Methylxanthine relaxes the spontaneous tension of isolated guinea pig tracheal smooth muscle preparations. Through a DRD1-dependent pathway, 3-Methylxanthine upregulates the expression of γH2AX and activated caspase-3, downregulates the expression of Bcl-2, and enhances Cisplatin-induced apoptosis (apoptosis) in ovarian cancer cells both in vitro and in vivo. 3-Methylxanthine induces clonic convulsions in the central nervous system. 3-Methylxanthine is the major metabolite of Theophylline (HY-B0809). 3-Methylxanthine can be used in studies related to ovarian cancer and neurotoxic convulsions .
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