1 Result for "

3010256-54-6

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3010256-54-6" in MCE Product Catalog:

Cat. No.: HY-155965
CAS No.: 3010256-54-6
Target:  

VEGFR PARP Apoptosis

Research Areas:  

Cancer

VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis, and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells (IC50: 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent .
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