1 Result for "

3053537-06-4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3053537-06-4" in MCE Product Catalog:

Cat. No.: HY-168867
CAS No.: 3053537-06-4
Target:  

PROTACs RET Apoptosis

Research Areas:  

Cancer

RD-23 is an orally active and selective RET PROTAC degrader, with DC50 values of 5.6 nM and 11.7 nM against RET WT and RET G810C mutants, respectively. RD-23 inhibits purified RET kinase activity with an IC50 of 0.371 nM. RD-23 suppresses the activation of downstream Shc signaling and induces apoptosis. RD-23 can be used for the research of RET-related cancers .
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