1 Result for "

3118499-89-8

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3118499-89-8" in MCE Product Catalog:

Cat. No.: HY-172208
CAS No.: 3118499-89-8
Research Areas:  

Inflammation/Immunology

PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC50 values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis .
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