1 Result for "

3121532-43-9

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3121532-43-9" in MCE Product Catalog:

Cat. No.: HY-P11928
CAS No.: 3121532-43-9
Target:  

CCR ERK

Research Areas:  

Cancer

TC6-D3 is a proteolysis-resistant peptide and also a CC chemokine receptor 7 (CCR7) inhibitor, with a Kd value of 403 nM against mouse targets. TC6-D3 blocks the interaction between CCR7 and its ligands CCL19 and CCL21, and inhibits the activation of the ERK1/2 pathway. TC6-D3 reduces the migratory capacity of tumor cells in vitro. TC6-D3 inhibits tumor growth and lymph node metastasis in vivo. TC6-D3 restores T cell cytotoxicity, promotes CD8+ T cell infiltration, and enhances anti-tumor immune responses. TC6-D3 can be used in studies related to lymph node metastasis .
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