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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
ACE2-transgenic mice
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "ACE2-transgenic mice" in MCE Product Catalog:
Cat. No.: HY-184485
Research Areas:
MB-32 is a potent and selective allosteric inhibitor of human angiotensin-converting enzyme 2 (hACE2) with a Kd value of 7.078 μM. MB-32 binds to a non-catalytic surface pocket on the N-terminal helix of ACE2, disrupts the interaction between ACE2 and the receptor-binding domain of SARS-CoV-2 spike protein through allosteric action, and preserves the enzymatic activity of ACE2 across different species. MB-32 achieves high concentrations in the airway via intranasal administration, with no detected cardiovascular toxicity. MB-32 can be used for research on coronavirus disease 2019 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
