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AChE/MAO-B-IN-9

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-181861
    AChE/MAO-B-IN-9

    		Cholinesterase (ChE) Monoamine Oxidase Amyloid-β Tau Protein Neurological Disease
    AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC50 of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease .
    AChE/MAO-B-IN-9

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