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Results for "

AG-85

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Fluorescent Dye

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19640
    AG-85

    		Bacterial Infection
    AG-85 is a major secretion protein of Mycobacterium tuberculosis, and can be identified in ancient bone .
    AG-85
  • HY-172298
    (R,S,S,S)-Orlistat

    (R,S,S,S)-Tetrahydrolipstatin; (R,S,S,S)-Ro-18-0647

    		 Fatty Acid Synthase (FASN) Infection
    (R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE .
    (R,S,S,S)-Orlistat
  • HY-D3391
    RMR-Tre

    		Bacterial Infection
    RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .
    RMR-Tre

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