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Results for "

ATF4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Aminoacyl-tRNA Synthetase (2) AMPK (1) Apoptosis (18) Atg8/LC3 (3) Autophagy (6) Bcl-2 Family (4) Biochemical Assay Reagents (1) c-Myc (1) Caspase (4) DAPK (1) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Environmental Pollutants (1) Epigenetic Reader Domain (4) ERK (1) Eukaryotic Initiation Factor (eIF) (13) Ferroptosis (1) FOXO (1) Glutathione Peroxidase (3) HDAC (1) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (1) Interleukin Related (1) IRE1 (3) Isocitrate Dehydrogenase (IDH) (1) JAK (3) JNK (3) Keap1-Nrf2 (1) MDM-2/p53 (1) MetAP (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitogen- and Stress-Activated Protein Kinase (MSK) (1) mTOR (1) MyD88 (2) NF-κB (3) Nuclear Hormone Receptor 4A/NR4A (2) Orphan GPCR (1) p38 MAPK (3) p62 (3) PARP (2) PD-1/PD-L1 (1) PERK (7) PI3K (1) PINK1/Parkin (1) PKA (1) PROTACs (1) Protein Arginine Deiminase (1) Reactive Oxygen Species (ROS) (7) Reference Standards (2) Sigma Receptor (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) SOD (1) STAT (3) STING (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (33) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (9) Metabolic Disease (7) Neurological Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Antibodies

Oligonucleotides

Targets Recommended: ATF6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Endogenous Metabolite	Neurological Disease Cancer
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

HY-112654

GCN2iB Maximum Cited Publications 60 Publications Verification	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC₅₀ of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates *GPX4*. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .

HY-158202

ATF4-IN-2	Epigenetic Reader Domain	Neurological Disease
ATF4-IN-2 (Compound 29) is a *ATF4* inhibitor with a IC₅₀ value of 47.71 nM. ATF4-IN-2 can be used in the study of neurodegenerative diseases .

HY-100548

GSK621 5+ Cited Publications	AMPK Autophagy Apoptosis	Cancer
GSK621 is a specific AMPK activator, with IC₅₀ values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation .

HY-160196

HC-7366 GCN2 modulator-1	Eukaryotic Initiation Factor (eIF)	Cancer
HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC₅₀ being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as *ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC₅₀* being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia .

HY-158201

ATF4-IN-1	Eukaryotic Initiation Factor (eIF)	Neurological Disease
ATF4-IN-1 (Compound 21) is an *ATF4* inhibitor and also an eIF2B activator. ATF4-IN-1 can be used in research on neurodegenerative diseases .

HY-147831

HR-19011	Eukaryotic Initiation Factor (eIF) Epigenetic Reader Domain	Cancer
HR-19011 is an eIF2α phosphorylation activator targeting heme-regulated inhibitor HRI (EIF2AK1). HR-19011 exhibits growth inhibitory activity against K562 cells with an IC₅₀ value of 3.91 µM. HR-19011 inhibits the growth of hematologic malignancies by targeting HRI to activate the integrated stress response via the HRI-eIF2α-ATF4 axis. HR-19011 shows good safety in vivo. HR-19011 can be used for research on hematologic malignancies (leukemia) .

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, *Rassf4, MyoD1, Grem1, and DAPK1* proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, *ATF4* and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research ^[4] .

HY-170872

PT-129	PROTACs DNA/RNA Synthesis	Cancer
PT-129 is a G3BP1/G3BP2 PROTAC degrader. PT-129 inhibits the formation of stress granules, disassembles pre-existing stress granules, disrupts stress granule-mediated *ATF4* trafficking via migratory exocytosis, and suppresses cancer cell proliferation. PT-129 is applicable to the research of lung cancer and melanoma .

HY-153340

I-152	Keap1-Nrf2	Metabolic Disease
I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and *ATF4* signals. I-152 has anti-proliferative properties .

HY-153339

E235	Eukaryotic Initiation Factor (eIF)	Cancer
E235 is an expression regulator of activates transcription factor 4 (ATF4). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research .

HY-153074

ISR-IN-1	Eukaryotic Initiation Factor (eIF)	Cancer
ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC₅₀: 0.6 nM) .

HY-124646

KIRA-7	IRE1	Inflammation/Immunology
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC₅₀ of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect .

HY-RS01130

ATF4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATF4 Human Pre-designed siRNA Set A contains three designed siRNAs for ATF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATF4 Human Pre-designed siRNA Set A ATF4 Human Pre-designed siRNA Set A

HY-158203

BMP agonist 2	TGF-β Receptor	Others
BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the *BMP2-ATF4* signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) .

HY-W020952

Palladium(Ⅱ) acetylacetonate Palladium(Ⅱ) 2,4-pentanedionate; Pd(acac)2	Biochemical Assay Reagents HSP Eukaryotic Initiation Factor (eIF) IRE1 JNK Apoptosis	Cancer
Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, *ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis*. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer .

HY-117938

T-3861174	Aminoacyl-tRNA Synthetase	Cancer
T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the *GCN2-ATF4* pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight .

HY-158196

PERK/eIF2α activator 1	PERK Apoptosis	Cancer
PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC₅₀ value of 23 μM .

HY-121337

Flurochloridone R-40244	Environmental Pollutants Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating *eIF2α-ATF4/ATF6-CHOP-Bim/Bax* signaling pathways in TM4 cells .

HY-112903A

YW3-56 hydrochloride	Protein Arginine Deiminase MDM-2/p53 PERK mTOR Autophagy	Cancer
YW3-56 (hydrochloride) is a PAD inhibitor. YW3-56 (hydrochloride) activates p53 target genes. YW3-56 (hydrochloride) activates *ATF* and blocks autophagy flux. YW3-56 induces ER stress through the *PERK-eIF2α-ATF4* signaling cascade and inhibits the mTOR signaling. YW3-56 (hydrochloride) inhibits triple-negative breast cancer .

HY-13559

Atiprimod Azaspirane ; SKF 106615-12; SKF 106615A12	STAT Apoptosis Autophagy Reactive Oxygen Species (ROS) Caspase Bcl-2 Family p62 Atg8/LC3 PARP NF-κB PERK JAK	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[4] .

HY-171438

ATF4 agonist-1	Epigenetic Reader Domain	Others
ATF4 agonist 1 (Compound 298) is a *ATF4* agonist and integrated stress pathway modulator .

HY-RS16552

Atf4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atf4 Mouse Pre-designed siRNA Set A Atf4 Mouse Pre-designed siRNA Set A

HY-153075

ISR-IN-2	Eukaryotic Initiation Factor (eIF)	Cancer
ISR-IN-2 (Compound 47) is an inhibitor of the integrated stress response (EC₅₀: 0.8 nM) .

HY-178154

FB231	PINK1/Parkin Mitochondrial Metabolism	Neurological Disease
FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease .

HY-RS22985

Atf4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atf4 Rat Pre-designed siRNA Set A Atf4 Rat Pre-designed siRNA Set A

HY-121033

BS148	Sigma Receptor p38 MAPK Apoptosis	Cancer
BS148 is a selective sigma-2 receptor (S2R) agonist with a K_i 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma .

HY-162886

BSO-07	JNK Reactive Oxygen Species (ROS)	Cancer
BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC₅₀ value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .

HY-158195

DPP23	Apoptosis	Cancer
DPP23 exerts antitumor activity through ROS-mediated apoptosis in cancer cells, but does not play a role in healthy cells. DPP23 can up-regulate the expression of ATF4 .

HY-13559A

Atiprimod dimaleate Azaspirane dimaleate; SKF 106615-12 dimaleate; SKF 106615A12 dimaleate	STAT Apoptosis Caspase Interleukin Related Autophagy Reactive Oxygen Species (ROS) Atg8/LC3 p62 JAK	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) (dimaleate) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[4] .

HY-110102

Atiprimod hydrochloride Azaspirane hydrochloride; SKF 106615-12 hydrochloride; SKF 106615	JAK STAT Apoptosis Autophagy Reactive Oxygen Species (ROS) Caspase Atg8/LC3 p62	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) hydrochloride is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[4] .

HY-172784

Anticancer agent 273	PI3K Akt Apoptosis	Cancer
Anticancer agent 273 (Compound 9q) is a potent anticancer agent found in matrine. Anticancer agent 273 inhibits the proliferation of cancer cells (e.g., HeLa cells with an IC₅₀ value of 4.48 μM). Anticancer agent 273 exerts anticancer effects by modulating the expression of PI3K/AKT and activating transcription factor 4 (ATF4), which promotes endoplasmic reticulum stress and induces apoptosis. Anticancer agent 273 is promising for research of cancers, such as cervical cancer .

HY-138844

3-AP-Me	Eukaryotic Initiation Factor (eIF) p38 MAPK JNK Apoptosis	Cancer
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .

HY-158205

HPO-DAEE 4-Hydroperoxy-2-decenoic acid ethyl ester	Reactive Oxygen Species (ROS) HDAC SOD	Inflammation/Immunology Cancer
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways .

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-121337R

Flurochloridone (Standard) R-40244 (Standard)	Reference Standards Apoptosis Bcl-2 Family	Others
Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-170849

Nur77 modulator 4	Nuclear Hormone Receptor 4A/NR4A Apoptosis PERK IRE1	Cancer
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a K_D of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC₅₀ of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the *PERK-ATF4* and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	Orphan GPCR Glutathione Peroxidase Ferroptosis ERK Toll-like Receptor (TLR) Sirtuin FOXO Akt PKA MyD88 Reactive Oxygen Species (ROS) Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the *HMGB1/TLR4/MyD88/NF-κB* signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the *ATF4/SLC7A11/GPX4* axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on ^[4].

HY-182781

Anticancer agent 313	MetAP	Cancer
Anticancer agent 313 is a MetAP2 inhibitor with an IC₅₀ of 4.11 μM. Anticancer agent 313 activates the transcription factor *ATF4* via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer .

HY-183332

YXX0248	Others	Inflammation/Immunology
YXX0248 is an orally active anti-hypoxic agent. YXX0248 upregulates mRNA expression of FGF21 and GDF15 via activation of the *ISR/ATF4* transcriptional axis. YXX0248 exhibits low cytotoxicity. YXX0248 enhances hypoxic survival in mice. YXX0248 can be used for the research of acute mountain sickness and hypoxia-related diseases .

HY-181959

APL-4098	Eukaryotic Initiation Factor (eIF)	Cancer
APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a K_i of 4.39 nM and a K_d of 2.9 nM. APL-4098 reduces the phosphorylation level of eIF2α and the expression level of *ATF4*. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia .

HY-180490

eIF3e-IN-1	HIF/HIF Prolyl-Hydroxylase Epigenetic Reader Domain	Cancer
eIF3e-IN-1 (Compound 209) is an elF3e inhibitor with an EC₅₀ of 18.3 μM. eIF3e-IN-1 significantly reduces the accumulation of HIF1α protein induced by hypoxia and inhibits the acute translation hypoxia response. eIF3e-IN-1 significantly inhibits the expression of ATF4 protein. eIF3e-IN-1 can be used in cancer research, such as in breast cancer studies .

HY-183331

YXX0237	Others	Infection Inflammation/Immunology
YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the *ISR/ATF4* transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases .

HY-112654A

GCN2iB acetate	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB acetate is an ATP-competitive, selective GCN2 inhibitor with an IC₅₀ of 2.4 nM. GCN2iB acetate inhibits the activation of the GCN2 pathway and upregulates *GPX4*. GCN2iB acetate enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB acetate increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB acetate can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .

HY-182360

Cytisine-platinum(IV) prodrug-1	PERK Eukaryotic Initiation Factor (eIF) Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS) STING DNA/RNA Synthesis PD-1/PD-L1	Cancer
Cytisine-Platinum(IV) Prodrug-1 is a Pt(IV) prodrug incorporating the natural compound Cytisine (HY-N0175) with antiproliferative activity against tumor cells. Cytisine-Platinum(IV) Prodrug-1 promotes calcium transfer across the IP3R1-GRP75-VDAC1 axis to drive mitochondrial calcium overload. Cytisine-Platinum(IV) Prodrug-1 initiates unfolded protein response via PERK, eIF2α, *ATF4, and CHOP* to modulate Bcl-2 and Bax, triggering apoptosis. Cytisine-Platinum(IV) Prodrug-1 induces mitochondrial dysfunction, ROS production, reduced ATP synthesis, DNA damage, and S-phase cell cycle arrest. Cytisine-Platinum(IV) Prodrug-1 activates the cGAS-STING pathway, reduces PD-L1 expression, drives immunogenic cell death. Cytisine-Platinum(IV) Prodrug-1 exhibits high physiological stability, efficient cellular accumulation, and enhanced platinum-DNA binding, and inhibits tumor growth in mouse models with reduced systemic toxicity. Cytisine-Platinum(IV) Prodrug-1 can be used for the research of lung cancer .

HY-W097625R

6-Methoxyflavone (Standard)	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO) Reference Standards PERK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[4] .

HY-183004

NCP26	Aminoacyl-tRNA Synthetase Apoptosis Caspase PARP c-Myc	Cancer
NCP26 is an ATP-competitive ProRS inhibitor (with a K_D of 271 nM in the absence of proline, and a K_D of 0.35 nM in the presence of 100 μM proline). NCP26 activates AAR, induces G0/G1 phase arrest, Apoptosis, Caspase cleavage, and PARP cleavage. NCP26 downregulates MYC, TCF3, and CCND1. NCP26 inhibits the growth of multiple myeloma cells. NCP26 can be used for the research of multiple myeloma .

HY-183704

ISR activator-5	Eukaryotic Initiation Factor (eIF) Mitogen- and Stress-Activated Protein Kinase (MSK)	Neurological Disease Metabolic Disease Cancer
ISR activator-5 is an eIF2B modulator and integrated stress response (ISR) activator. ISR activator-5 stabilises the inactive I-state of eIF2B, inhibits protein synthesis, and activates canonical ISR pathways without inducing eIF2α phosphorylation. ISR activator-5 can be used for the research of cancer, neurologic and metabolic disorders .

HY-182938

Autophagy activator-2	Autophagy	Metabolic Disease
Autophagy activator-2 is a potent autophagy activator with EC₅₀ values of 14.33 μM. Autophagy activator-2 acts as a proteostasis modulator and small-molecule chaperone that upregulates I1061T mutant NPC1 expression and facilitates cholesterol efflux. Autophagy activator-2 reduces lysosomal hydrolase levels. Autophagy activator-2 can be used for the study of Niemann-Pick Type C disease .

Cat. No.	Product Name	Type

HY-W020952

Palladium(Ⅱ) acetylacetonate Palladium(Ⅱ) 2,4-pentanedionate; Pd(acac)2	Biochemical Assay Reagents
Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, *ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis*. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer .

Cat. No.	Product Name	Target	Research Area

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	Orphan GPCR Glutathione Peroxidase Ferroptosis ERK Toll-like Receptor (TLR) Sirtuin FOXO Akt PKA MyD88 Reactive Oxygen Species (ROS) Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the *HMGB1/TLR4/MyD88/NF-κB* signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the *ATF4/SLC7A11/GPX4* axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on ^[4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

HY-W097625R

6-Methoxyflavone (Standard)	Structural Classification Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell. Source Classification	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO) Reference Standards PERK
6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[4] .

Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (3) Mouse (3)
Application:	IHC-P (5) ICC/IF (3) IP (3) WB (6) FC (2) ELISA (3)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Polyclonal (2) Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80486

	ATF4 Antibody (YA605) 1 Publications Verification	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	ATF4 Antibody (YA605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF4.

HY-P86576

	ATF4 Antibody (YA6268) ATF4; CREB2; TXREB; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding prot	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATF4 Antibody (YA6268) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF4.

HY-P84148

	ATF4 Antibody (YA3845) CREB2; TXREB; CREB-2; TAXREB67	WB, IHC-P, ELISA	Human
	ATF4 Antibody (YA3845) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATF4.

HY-P80553

	ATF4 Antibody 2 Publications Verification Cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	ATF4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ATF4.

HY-P84148A

	ATF4 Antibody (YA3845)(PBS only) CREB2; TXREB; CREB-2; TAXREB67	WB, IHC-P, ELISA	Human
	ATF4 Antibody (YA3845) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATF4.

HY-P83667

	*Phospho-ATF4* (Ser219) Antibody** Cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67	WB	Human
	Phospho-ATF4 (Ser219) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-ATF4 (Ser219).

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