1 Result for "

AZ'4331

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AZ'4331" in MCE Product Catalog:

Cat. No.: HY-189200
CAS No.: 3006101-94-3
Target:  

YAP Hippo (MST)

Research Areas:  

Cancer

AZ'4331 is an orally active pan-TEAD family inhibitor, with an IC50 of 0.381 μM against TEAD1, 0.020 μM against TEAD2, 0.014 μM against TEAD3, and 0.031 μM against TEAD4. AZ'4331 slows cell cycle progression. AZ'4331 exerts effects in cancer xenograft models with dysregulated Hippo pathway. AZ'4331 can be used to study cancers with altered Hippo pathways, including mesothelioma, head and neck squamous cell carcinoma, and EGFR-mutant non-small cell lung cancer .
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