Ang1

By Targets:	5-HT Receptor (1) Akt (1) AMPK (1) Angiotensin Receptor (7) Angiotensin-converting Enzyme (ACE) (4) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (1) Caspase (1) EGFR (1) Endogenous Metabolite (3) FABP (1) FAK (1) GLUT (1) HSP (1) IAP (1) JNK (1) MDM-2/p53 (1) mTOR (1) NF-κB (1) p38 MAPK (1) Parasite (1) PARP (1) PERK (1) Phosphatase (3) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Small Interfering RNA (siRNA) (6) SOD (1) STAT (1) Tie (6) TNF Receptor (1) VEGFR (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (9) Endocrinology (5) Infection (1) Inflammation/Immunology (8)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12403

Talfirastide 15+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

HY-109041

Razuprotafib 4 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) ^[1].

HY-P0216

A 779 Maximum Cited Publications 19 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches ^[1] .

HY-P99546

Trebananib 2xCon4C; AMG 386	Tie	Cardiovascular Disease Cancer
Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the TIE2 receptor. Trebananib has anti-angiogenic and anti-tumor activities ^[1] .

HY-N2445

Flavokawain C 4 Publications Verification	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK	Cancer
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces *PARP-1* cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins *GLUT1* and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of *HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1* and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer ^[1] .

HY-12403A

Talfirastide acetate 15+ Cited Publications TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium ^[1] .

HY-15778A

AVE 0991 sodium salt 10+ Cited Publications	Angiotensin Receptor	Cardiovascular Disease Endocrinology
AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [ ¹²⁵I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC₅₀ of 21 nM ^[1].

HY-P991663

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both *Ang1* and *Ang2*. AMG-780 is indicated for the research of cancers such as colon cancer ^[1] .

HY-W342283

Diminazene	Parasite Angiotensin-converting Enzyme (ACE) Angiotensin Receptor p38 MAPK STAT NF-κB TNF Receptor 5-HT Receptor	Cardiovascular Disease Infection Inflammation/Immunology
Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the *ACE2/Ang-(1-7)/Mas* receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation ^[1] .

HY-12403R

Talfirastide (Standard) TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

HY-RS14612

TM7SF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TM7SF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TM7SF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TM7SF2 Human Pre-designed siRNA Set A TM7SF2 Human Pre-designed siRNA Set A

HY-RS00687

ANGPT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ANGPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ANGPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ANGPT1 Human Pre-designed siRNA Set A ANGPT1 Human Pre-designed siRNA Set A

HY-109041A

Razuprotafib sodium AKB-9778 sodium	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) ^[1].

HY-109041R

Razuprotafib (Standard) AKB-9778 (Standard)	Reference Standards Phosphatase Tie	Inflammation/Immunology
Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) ^[1].

HY-160043

AL6 aptamer sodium	Biochemical Assay Reagents	Cancer
AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .

HY-RS17668

Angpt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Angpt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Angpt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Angpt1 Mouse Pre-designed siRNA Set A Angpt1 Mouse Pre-designed siRNA Set A

HY-RS23274

Ang Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ang Rat Pre-designed siRNA Set A contains three designed siRNAs for Ang gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ang Rat Pre-designed siRNA Set A Ang Rat Pre-designed siRNA Set A

HY-RS16832

Ang Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ang Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ang gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ang Mouse Pre-designed siRNA Set A Ang Mouse Pre-designed siRNA Set A

HY-RS24129

Angpt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Angpt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Angpt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Angpt1 Rat Pre-designed siRNA Set A Angpt1 Rat Pre-designed siRNA Set A

HY-P0216A

A-779 TFA	Angiotensin Receptor	Cardiovascular Disease
A-779 TFA is a selective angiotensin-(1-7) (Ang-(1-7)) antagonist. A-779 TFA blocks Arachidonic acid release, bradykinin potentiation effects and hypotensive action. A-779 TFA exerts diuretic effects in non-pregnant rats, antidiuretic effects in late-pregnant rats, and also inhibits feed intake and water consumption in late-pregnant rats. A-779 TFA attenuates the regulatory effects of prostacyclin, nitric oxide and thromboxane A₂ associated with angiotensin-(1-7). A-779 TFA can be used in studies related to hypertension ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-12403

Talfirastide 15+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

HY-P0216

A 779 Maximum Cited Publications 19 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.

HY-12403A

Talfirastide acetate 15+ Cited Publications TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium ^[1] .

HY-12403R

Talfirastide (Standard) TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

HY-P0216A

A-779 TFA	Angiotensin Receptor	Cardiovascular Disease
A-779 TFA is a selective angiotensin-(1-7) (Ang-(1-7)) antagonist. A-779 TFA blocks Arachidonic acid release, bradykinin potentiation effects and hypotensive action. A-779 TFA exerts diuretic effects in non-pregnant rats, antidiuretic effects in late-pregnant rats, and also inhibits feed intake and water consumption in late-pregnant rats. A-779 TFA attenuates the regulatory effects of prostacyclin, nitric oxide and thromboxane A₂ associated with angiotensin-(1-7). A-779 TFA can be used in studies related to hypertension ^[1] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches ^[1] .

HY-P99546

Trebananib 2xCon4C; AMG 386	Tie	Cardiovascular Disease Cancer
Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the TIE2 receptor. Trebananib has anti-angiogenic and anti-tumor activities ^[1] .

HY-P991663

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both *Ang1* and *Ang2*. AMG-780 is indicated for the research of cancers such as colon cancer ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12403

Talfirastide 15+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

HY-N2445

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces *PARP-1* cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins *GLUT1* and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of *HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1* and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer ^[1] .

HY-12403A

Talfirastide acetate 15+ Cited Publications TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium ^[1] .

HY-12403R

Talfirastide (Standard) TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards
Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity ^[1] .

Recombinant Proteins Recommended:

ANG-1

Species:	Human (1) Mouse (2) Rat (1) Cynomolgus (2)
Tag:	His (4) Fc (2)
Source:	HEK293 (5) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700560

	ANGPT1/Angiopoietin-1, Rat (P. pastoris, His) Angiopoietin 1; Angiopoietin-1; Ang1; KIAA0003; Ang-1; AGP1; AGPT; Ang1	Rat	P. pastoris
	In rats, ANGPT1 (Angiopoietin-1) activates the TIE2 receptor, inducing tyrosine phosphorylation and influencing endothelial developmental processes distinct from VEGF. ANGPT1 plays a crucial role in mediating reciprocal interactions between endothelium, matrix, and mesenchyme. It participates in blood vessel maturation, emphasizing its significance in vascular development, with a potential role in early heart development. ANGPT1/Angiopoietin-1, Rat (P. pastoris, His) is the recombinant rat-derived ANGPT1/Angiopoietin-1, Rat, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70061

	Angiopoietin-1 Protein, Human (HEK293, Fc) 2 Publications Verification rHuAngiopoietin-1/Ang1, Fc; AGP1; AGPT; Ang1; Ang-1; Angiopoietin 1; Angiopoietin-1; AngPT1	Human	HEK293
	Angiopoietin-1 Protein, Human (HEK 293, Fc) is a secreted protein located on the outside of cell membranes and is an agonistic ligand of receptor tyrosine kinase that is mainly expressed by vascular endothelial cells and hematopoietic cells. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a potent inducer of sprouting angiogenesis, proming for research of colorectal cancer liver metastases (CRCLMs). Angiopoietin-1 Protein, Human (HEK 293, Fc) induces vascular remodeling through highly organized angiogenesis and tightening of endothelial cell (EC) junctions. Angiopoietin-1 Protein, Human (HEK 293, Fc) regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and maintenance of vascular quiescence. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a recombinant protein with a Fc label that consisting of 498 amino acids and is expressed in HEK293 cells.

HY-P76145

	Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1	Cynomolgus	HEK293
	The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Angiopoietin-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76146

	Angiopoietin-1 Protein, Cynomolgus (HEK293, His) AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1	Cynomolgus	HEK293
	The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. Angiopoietin-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74412A

	Angiopoietin-1 Protein, Mouse (HEK293, His) 1 Publications Verification AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1	Mouse	HEK293
	Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74412

	Angiopoietin-1 Protein, Mouse (HEK293, His, solution) AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1	Mouse	HEK293
	Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.

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HY-P81847

	Angiopoietin 1 Antibody (YA1592) AngPT1; KIAA0003; Angiopoietin-1; Ang-1	WB	Human, Rat
	Angiopoietin 1 Antibody (YA1592) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiopoietin 1.

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Cat. No.	Product Name		Classification

HY-RS14612

TM7SF2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TM7SF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TM7SF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00687

ANGPT1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ANGPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ANGPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-160043

AL6 aptamer sodium		Aptamers
AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .

HY-RS17668

Angpt1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Angpt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Angpt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23274

Ang Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ang Rat Pre-designed siRNA Set A contains three designed siRNAs for Ang gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16832

Ang Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ang Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ang gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24129

Angpt1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Angpt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Angpt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Peptides

Inhibitory Antibodies

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Recombinant Proteins

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Ang1

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products