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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Angiotensinogen Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Angiotensinogen Inhibitors" in MCE Product Catalog:
Cat. No.: HY-147406
CAS No.: 2589926-20-3
Synonyms: ION-904
Target:
Cat. No.: HY-147267
CAS No.: 2589926-22-5
Synonyms: ISIS-757456
Target:
Research Areas:
Evazarsen is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties .
Cat. No.: HY-145649A
CAS No.: 2380166-34-5
Synonyms: AD-85481 sodium; ALN-AGT sodium
Research Areas:
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension .
Cat. No.: HY-109034A
CAS No.: 1202269-24-6
Synonyms: AK-272; SCO-272
Target:
Research Areas:
Imarikiren hydrochloride (AK-272) is an orally active, selective Renin inhibitor with an IC50 value of 2.1 nM against h-Renin. Imarikiren hydrochloride blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren hydrochloride alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren hydrochloride can be used in research related to hypertension and heart failure .
Cat. No.: HY-147267A
CAS No.: 2589926-24-7
Synonyms: ISIS-757456 sodium
Target:
Research Areas:
Evazarsen sodium is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties .
Cat. No.: HY-147406A
CAS No.: 2589926-21-4
Synonyms: ION-904 sodium
Target:
Cat. No.: HY-129412
CAS No.: 130316-95-9
Target:
Research Areas:
A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension .
Cat. No.: HY-185922
CAS No.: 3080217-81-5
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Research Areas:
Baslisiran is an angiotensinogen (AGT) synthesis inhibitor that can be used in studies related to hypertension .
Cat. No.: HY-109034
CAS No.: 1202265-63-1
Synonyms: AK-272 free base; SCO-272 free base
Target:
Research Areas:
Imarikiren (AK-272 free base) is an orally active, selective Renin inhibitor with an IC50 value of 2.1 nM against h-Renin. Imarikiren blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren can be used in research related to hypertension and heart failure .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
