1202269-24-6
Chemical Structure
Imarikiren hydrochloride
- CAS No.: 1202269-24-6
- Formula:C27H42ClN5O4
- Molecular Weight:536.11
IUPAC Name: N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide hydrochloride
InChIKey: PUXOYQIZZIWCHH-NSLUPJTDSA-N
SMILES: COCCCCN1C(C(N([C@H]2C[C@H](CNC2)C(N3CCOCC3)=O)CC(C)C)=O)=NC4=CC=CC=C14.Cl
Biological Activity: Imarikiren hydrochloride is a renin inhibitor. Imarikiren hydrochloride can be used for the study of cardiovascular and renal diseases such as hypertension, heart failure, and diabetic nephropathy by blocking the renin-angiotensin (RA) system[1].
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Imarikiren hydrochloride | Imarikiren hydrochloride is a renin inhibitor. Imarikiren hydrochloride can be used for the study of cardiovascular and renal diseases such as hypertension, heart failure, and diabetic nephropathy by blocking the renin-angiotensin (RA) system. | |||||||||||||||||||||
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- [1]. Matsuno K, et al. A Randomized, Single-Center, Double-Blind, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Imarikiren in Healthy Adult Nonelderly and Elderly Male Subjects. J Clin Pharmacol. 2018 Nov;58(11):1516-1524. [Content Brief]
Keywords
