3 Results for "

Auristatin0101

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Auristatin0101" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-12522S
CAS No.: 3020284-76-5
Purity:  99.37%
Synonyms: Aur0101-d8; Auristatin-0101-d8
PF-06380101-d8 (Aur0101-d8) is a deuterium labeled PF-06380101 (HY-12522). PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue .
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Cat. No.: HY-12522
CAS No.: 1436391-86-4
Purity:  99.47%
Synonyms: Aur0101; Auristatin-0101
Research Areas:  

Cancer

PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
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Cat. No.: HY-P99829
CAS No.: 1869937-48-3
Synonyms: PF-06647020; ABBV-647; h6M24-vc0101
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
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