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Biflavonoids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Amyloid-β (1) Apoptosis (4) Autophagy (1) Caspase (1) DNA/RNA Synthesis (1) Drug Derivative (1) HBV (1) HIV (1) IAP (1) Microtubule/Tubulin (1) NF-κB (3) Parasite (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) RSV (1) SARS-CoV (1) Survivin (1) TNF Receptor (2) Tyrosinase (1)
By Research Areas:	Cancer (10) Infection (4) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2119

Sciadopitysin 3 Publications Verification	TNF Receptor NF-κB	Inflammation/Immunology
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

HY-N10093

Chamaejasmine Chamaejasmin	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS)	Cancer
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of AMPK/mTOR signal pathway .

HY-133721

Chamaechromone	HBV	Infection Inflammation/Immunology
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .

HY-N5013

Robustaflavone	Others	Metabolic Disease
Robustaflavone is a biflavonoid isolated from Doradilla that has natriuretic properties .

HY-N4300

4'-O-Methylochnaflavone 1 Publications Verification	Others	Inflammation/Immunology
4'-O-Methylochnaflavone is a biflavonoid isolated from Lonicera japonica, suppresses mouse lymphocyte proliferation .

HY-126412

Neochamaejasmine A	Apoptosis	Cancer
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and apoptosis in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

HY-N9861

Kayaflavone	Amyloid-β	Neurological Disease
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC₅₀ value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease .

HY-N10871

Neocryptomerin	SARS-CoV	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell. Neocryptomerin has favorable binding affinities in the active pocket of SARS-CoV-2. Neocryptomerin is the leading compound of rational compounds against COVID-19 .

HY-N2756

Amentoflavone 7,4',7'',4'''-tetramethyl ether	Others	Others
Amentoflavone 7,4',7'',4'''-tetramethyl ether, a biflavone, is a natural product that can be isolated from Selaginella moellendorffii .

HY-N1655

2,3-Dihydroamentoflavone 7,4'-dimethyl ether	Others	Cancer
2,3-Dihydroamentoflavone 7,4'-dimethyl ether is a biflavonoid, which can be isolated from the aerial parts of Selaginella delicatula. 2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities against P-388 and HT-29 cell lines, with ED₅₀ (median effective dose) values of 3.50 and 5.25 µg/mL, respectively .

HY-124537

(+)-Volkensiflavone	Others	Others
(+)-Volkensiflavone is a biflavonoid, that can be isolated from the fruits of Garcinia livingstonei (Clusiaceae) .

HY-N1658

2,3-Dihydroisoginkgetin	Tyrosinase	Others
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

HY-N16510

Cinnabarone	Others	Others
Cinnabarone is a biflavonoid that can be isolated from dragon's blood of Dracaena cinnabari. Cinnabarone is a reducing and stabilizing agent which can be used for formation of silver nanoparticles .

HY-N1659

2,3-Dihydropodocarpusflavone A	Others	Others
2,3-Dihydropodocarpusflavone A is a biflavonoid, which can be isolated from Cycas beddomei .

HY-N2119R

Sciadopitysin (Standard)	TNF Receptor Reference Standards NF-κB	Inflammation/Immunology
Sciadopitysin (Standard) is the analytical standard of Sciadopitysin. This product is intended for research and analytical applications. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

HY-N1649

2,3,2'',3''-Tetrahydroochnaflavone	Others	Cancer
2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC₅₀ of 8.2 µg/mL .

HY-N3497

Isochamaejasmin	NF-κB DNA/RNA Synthesis Parasite Apoptosis	Infection Cancer
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-N3205A

Isoneochamaejasmin A INCA	Others	Others
Isoneochamaejasmin A (INCA), a biflavonoid, is one of main active ingredients in the root of Stellera chamaejasme L .

HY-N10920

Genkwanol C	RSV	Infection
Genkwanol C, a biflavonoid, has effective antiviral activity against respiratory syncytial virus (RSV) in vitro .

HY-N10171

GB-2a	Others	Inflammation/Immunology
GB-2a is a bioflavonoids that can be isolated from Rheedia gardneriana. GB-2a has significant analgesic activity in mice with 58.9% inhibition .

HY-N17573

Zizyflavoside B	Others	Others
Zizyflavoside B is a diphenyl ether-type biflavonoid. Zizyflavoside B occurs in the leaves of Zizyphus spina-christi (L.) Willd .

HY-N18310

Robustaflavone 4′-methyl ether	Others	Cancer
Robustaflavone 4′-methyl ether is a biflavonoid compound that can be isolated from the whole plant of Selaginella gracillima. Robustaflavone 4′-methyl ether inhibits the growth of cancer cells. Robustaflavone 4′-methyl ether can be used in the research of EBV-transformed B-cell carcinoma and lung cancer .

HY-N9779

2,3-Dihydroamentoflavone	Others	Others
2,3-Dihydroamentoflavone is a biflavonoid compound that can be isolated from Selaginella sinensis .

HY-N18315

(2''S)-2'',3''-Dihydrodelicaflavone	Apoptosis Caspase IAP Survivin	Cancer
(2''S)-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii, which exhibits antiproliferative and apoptosis-inducing activities against non-small cell lung cancer cells. (2''S)-2'',3''-Dihydrodelicaflavone can be used in the research of non-small cell lung cancer .

HY-N16801

Genkwanol B	Drug Derivative	Others
Genkwanol B is a natural flavonoid.

HY-N9784

2′′,3′′-Dihydroochnaflavone	Others	Cancer
2′′,3′′-Dihydroochnaflavone is a flavonoid/flavanone-type ether-linked biflavonoid anti-leukemic compound. 2′′,3′′-Dihydroochnaflavone exhibits significant cytotoxicity against P388 murine lymphocytic leukemia cells (IC₅₀ = 3.1 μg/mL). It can be naturally extracted from the dried leaves of Quintinia acutifolia and has also been previously isolated and identified from Ochna interrima and Luxemburgia nobilis (both Ochnaceae plants). 2′′,3′′-Dihydroochnaflavone can be used in research related to anti-tumor (especially leukemia) applications .

HY-N16760

Wikstrol B	Microtubule/Tubulin HIV	Infection
Wikstrol B (compound 5) is a biflavonoid microtubule/tubulin inhibitor and HIV-1 inhibitor. Wikstrol B has an IC₅₀ value of 184 μM for microtubule polymerization and an EC₅₀ of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica .

HY-N18316

(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone	Others	Cancer
(2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone exhibits antiproliferative activity against non-small cell lung cancer cells (IC₅₀ = 3.1-6.8 μM) with low cytotoxicity toward normal cells. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone can be used in studies related to non-small cell lung cancer .

Sciadopitysin 3 Publications Verification	Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Plants Biflavones Ginkgo biloba Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor NF-κB
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS)
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of AMPK/mTOR signal pathway .

Chamaechromone	Flavonoids Classification of Application Fields Thymelaeaceae Phenols Polyphenols Plants Biflavones Disease Research Fields Inflammation/Immunology Source Classification Stellera chamaejasme L.	HBV
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .

Robustaflavone	Flavonoids Selaginella lepidophylla (Hook. & Grev.) Spring Selaginellaceae Plants Biflavones Source Classification	Others
Robustaflavone is a biflavonoid isolated from Doradilla that has natriuretic properties .

4'-O-Methylochnaflavone 1 Publications Verification	Caprifoliaceae Ginkgoaceae Classification of Application Fields Lonicera japonica Thunb. Plants Ginkgo biloba Flavonoids Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields Source Classification	Others
4'-O-Methylochnaflavone is a biflavonoid isolated from Lonicera japonica, suppresses mouse lymphocyte proliferation .

Neochamaejasmine A	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and apoptosis in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

Kayaflavone	Ranunculus ternatus Thunb. Flavonoids Flavones Ranunculaceae Plants Source Classification	Amyloid-β
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC₅₀ value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease .

Neocryptomerin	Flavonoids Taxodiaceae Plants Cunninghamia lanceolata var. konishii Biflavones Source Classification	SARS-CoV
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell. Neocryptomerin has favorable binding affinities in the active pocket of SARS-CoV-2. Neocryptomerin is the leading compound of rational compounds against COVID-19 .

Amentoflavone 7,4',7'',4'''-tetramethyl ether	Flavonoids Classification of Application Fields Selaginella moellendorffii Hieron. Other Diseases Selaginellaceae Plants Biflavones Disease Research Fields Source Classification	Others
Amentoflavone 7,4',7'',4'''-tetramethyl ether, a biflavone, is a natural product that can be isolated from Selaginella moellendorffii .

2,3-Dihydroamentoflavone 7,4'-dimethyl ether	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginella delicatula (Desv.) Alston Selaginellaceae Plants Biflavones Disease Research Fields Cancer Source Classification	Others
2,3-Dihydroamentoflavone 7,4'-dimethyl ether is a biflavonoid, which can be isolated from the aerial parts of Selaginella delicatula. 2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities against P-388 and HT-29 cell lines, with ED₅₀ (median effective dose) values of 3.50 and 5.25 µg/mL, respectively .

(+)-Volkensiflavone	Garcinia livingstonei T.Anderson Flavonoids Guttiferae Plants Biflavones Source Classification	Others
(+)-Volkensiflavone is a biflavonoid, that can be isolated from the fruits of Garcinia livingstonei (Clusiaceae) .

2,3-Dihydroisoginkgetin	Podocarpus macrophyllus (Thunb.) Sweet Flavonoids Classification of Application Fields Other Diseases Phenols Polyphenols Plants Podocarpaceae Biflavones Disease Research Fields Source Classification	Tyrosinase
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

Cinnabarone	Structural Classification Dracaena draco (L.) L. Phenols Polyphenols Agavaceae Plants Source Classification	Others
Cinnabarone is a biflavonoid that can be isolated from dragon's blood of Dracaena cinnabari. Cinnabarone is a reducing and stabilizing agent which can be used for formation of silver nanoparticles .

2,3-Dihydropodocarpusflavone A	Flavonoids other families Classification of Application Fields Pteridaceae Other Diseases Phenols Polyphenols Plants Biflavones Disease Research Fields Source Classification	Others
2,3-Dihydropodocarpusflavone A is a biflavonoid, which can be isolated from Cycas beddomei .

Sciadopitysin (Standard)	Structural Classification Flavonoids Ginkgoaceae Phenols Polyphenols Plants Biflavones Ginkgo biloba Source Classification	TNF Receptor Reference Standards NF-κB
Sciadopitysin (Standard) is the analytical standard of Sciadopitysin. This product is intended for research and analytical applications. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

2,3,2'',3''-Tetrahydroochnaflavone	Haplopteris anguste-elongata (Hayata) E. H. Crane Flavonoids Classification of Application Fields Phenols Polyphenols Plants Pteris vittata L. Biflavones Disease Research Fields Cancer Source Classification	Others
2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC₅₀ of 8.2 µg/mL .

Isochamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

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