69618-96-8
Chemical Structure
Chamaejasmine
Synonym(s): Chamaejasmin
- CAS No.: 69618-96-8
- Formula:C30H22O10
- Molecular Weight:542.49
IUPAC Name: (2R,2'R,3S,3'S)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-[3,3'-bichromane]-4,4'-dione
InChIKey: RNQBLQALVMHBKH-HHGOQMMWSA-N
SMILES: O=C1[C@]([C@@]2([H])[C@H](C3=CC=C(C=C3)O)OC4=CC(O)=CC(O)=C4C2=O)([H])[C@H](C5=CC=C(C=C5)O)OC6=CC(O)=CC(O)=C61
Biological Activity: Chamaejasmine (Chamaejasmin) is a natural biflavonoid found in the roots of Stellera chamaejasme, exhibiting antitumor activity. Chamaejasmine inhibits Bcl-2, upregulates Bax, and induces cleavage of caspase-9/-3 and PARP. Chamaejasmine induces ROS production, Δψm loss, cytochrome c release, G2/M arrest, apoptosis, and autophagy. Chamaejasmine induces apoptosis and autophagy through activation of AMPK and inhibition of mTOR, and inhibits microtubule depolymerization by binding to β-tubulin. Chamaejasmine inhibits IL-4, IgE, β-hexosaminidase, and mast cell infiltration, and improves skin barrier function in AD models. Chamaejasmine exhibits cytotoxicity against various cancer cells. Chamaejasmine can be used in research related to various cancers such as lung adenocarcinoma and osteosarcoma, as well as atopic dermatitis[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chamaejasmine | 98.17% | Chamaejasmine (Chamaejasmin) is a natural biflavonoid found in the roots of Stellera chamaejasme, exhibiting antitumor activity. Chamaejasmine inhibits Bcl-2, upregulates Bax, and induces cleavage of caspase-9/-3 and PARP. Chamaejasmine induces ROS production, Δψm loss, cytochrome c release, G2/M arrest, apoptosis, and autophagy. Chamaejasmine induces apoptosis and autophagy through activation of AMPK and inhibition of mTOR, and inhibits microtubule depolymerization by binding to β-tubulin. Chamaejasmine inhibits IL-4, IgE, β-hexosaminidase, and mast cell infiltration, and improves skin barrier function in AD models. Chamaejasmine exhibits cytotoxicity against various cancer cells. Chamaejasmine can be used in research related to various cancers such as lung adenocarcinoma and osteosarcoma, as well as atopic dermatitis. | ||||||||||||||||||||
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References
- [1]. Yu H, et al. Chamaejasmine induces apoptosis in human lung adenocarcinoma A549 cells through a Ros-mediated mitochondrial pathway. Molecules (Basel, Switzerland). 2011 Sep 27;16(10):8165-80.
- [2]. Yang D, et al. The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells. Bioscience reports. 2019 Jan 31;39(1):BSR20181707. [Content Brief]
- [3]. Kim TY, et al. Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice. Biomolecules. 2019 Nov 5;9(11):697.
- [4]. Fang W, et al. Anticancer activity of chamaejasmine: effect on tubulin protein. Molecules (Basel, Switzerland). 2011 Jul 25;16(8):6243-54.
