481-45-8
Chemical Structure
Kayaflavone
- CAS No.: 481-45-8
- Formula:C33H24O10
- Molecular Weight:580.54
IUPAC Name: 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: RROKRDUARFDCDH-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)OC)=C(OC)C=C2)OC6=C1C(O)=CC(O)=C6
Biological Activity: Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC50 of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases[1][2][3][4].
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Kayaflavone | 96.0% | Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC50 of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases. | ||||||||||||||||||||
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References
- [1]. Shen H, et al. Cytotoxic metabolites from the roots of Ranunculus ternatus. Chemistry of natural compounds. 2014 Oct;50(4):621-3.
- [2]. Hossain R, et al. Amentoflavone derivatives against SARS-CoV-2 main protease (MPRO): An in silico study. Main Group Chemistry. 2023 Jun 16;22(2):313-27.
- [3]. Yao H, et al. Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects. Molecules (Basel, Switzerland). 2017 Feb 20;22(2):325.
- [4]. Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. [Content Brief]
