5 Results for "

CCRF-CEM human leukemia cells

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "CCRF-CEM human leukemia cells" in MCE Product Catalog:

10-Formyl-7,8-dihydrofolic acid
10-Formyl-7,8-dihydrofolic acid
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Cat. No.: HY-137129
CAS No.: 28459-40-7
Purity:  97.70%
Category:  

Alkaloids Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Dihydrofolate reductase (DHFR)

10-Formyl-7,8-dihydrofolic acid is a biologically active folic acid and growth promoter. 10-Formyl-7,8-dihydrofolic acid serves as a substrate for aminoimidazolecarboxamide ribonucleotide transformylase and dihydrofolate reductase (DHFR) to support catalytic reactions (with detection wavelengths of 552 nm and 340 nm, respectively). 10-Formyl-7,8-dihydrofolic acid not only promotes the growth of leukemia cells, but also effectively reverses the growth inhibition induced by antifolate drugs under folate-deficient conditions. 10-Formyl-7,8-dihydrofolic acid can be used in the research of leukemia .
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(6aR,11aR)-Edunol
(6aR,11aR)-Edunol
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Cat. No.: HY-N17604
CAS No.: 33909-74-9
Category:  

Flavonoids Plants Other Flavonoids Fabaceae

Target:  

Drug Derivative

(6aR,11aR)-Edunol (compound 10) is a pterocarpan and antiproliferative agent. (6aR,11aR)-Edunol can be found in the roots of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx. (6aR,11aR)-Edunol exerts antiproliferative effects against drug-sensitive leukemia cells and multidrug-resistant leukemia cells. (6aR,11aR)-Edunol can be used for the research of leukemia .
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9-O-Angeloyl-8-methoxythymol
9-O-Angeloyl-8-methoxythymol
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Cat. No.: HY-N17588
CAS No.: 361541-62-0
Category:  

Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis

Target:  

Others

9-O-Angeloyl-8-methoxythymol is a thymol derivative and cytotoxin, with a IC50 value of 13.1 μg/mL against human myeloid leukemia cells, a IC50 value of 31.8 μg/mL against human lymphoblastic leukemia cells, and a IC50 >40 μg/mL against colon cancer and lymphoma cells. 9-O-Angeloyl-8-methoxythymol is applicable to leukemia-related research .
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LASSBio-2337
LASSBio-2337
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Cat. No.: HY-181710
Target:  

mTOR PI3K

Research Areas:  

Cancer

LASSBio-2337 is a dual pan-PI3K/mTOR inhibitor with an mTOR IC50 of 5.8 μM.LASSBio-2337 functionally modulates mTOR and all PI3K isoforms.LASSBio-2337 acts as a cytotoxic agent in leukemia cells, including multidrug-resistant populations.LASSBio-2337 spares nontumor human peripheral blood mononuclear cells.LASSBio-2337 displays moderate PAMPA-GIT permeability.LASSBio-2337 shows low metabolic stability in rat liver microsomes.LASSBio-2337 is aqueous insoluble.LASSBio-2337 can be used for the research of acute lymphoblastic leukemia, chronic myelogenous leukemia, breast cancer .
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Tasidotin
Tasidotin
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Cat. No.: HY-106021
CAS No.: 192658-64-3
Synonyms: ILX651 free base
Target:  

Microtubule/Tubulin Prolyl Endopeptidase (PREP)

Research Areas:  

Cancer

Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC50 of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .
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