2 Results for "

Cerebral contusion

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Cerebral contusion" in MCE Product Catalog:

Oligomycin B
Oligomycin B
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Cat. No.: HY-N6784
CAS No.: 11050-94-5
Category:  

Microorganisms Macrolide Antibiotics Antifungal Antibiotics Disease Research

Target:  

ATP Synthase Bacterial Apoptosis Antibiotic

Oligomycin B is an antibiotic that acts as a non-selective inhibitor of ATP Synthase. Oligomycin B increases mitochondrial membrane potential. Oligomycin B induces apoptosis and necrosis. Oligomycin B impairs the motility of Plasmopara viticola zoospores and induces their lysis. Oligomycin B inhibits Magnaporthe oryzae (wheat blast fungus) and suppresses the development of wheat blast. Oligomycin B reduces hyphal growth and spore germination of Botrytis cinerea, and protects Arabidopsis thaliana against Botrytis cinerea infection. Oligomycin B exacerbates cytotoxic brain edema in rats with cerebral cortical contusion, increases intracranial pressure and brain water content, and aggravates mitochondrial damage in these rats. Oligomycin B is used in studies related to grape downy mildew, traumatic brain injury, wheat blast, and gray mold .
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Opc 14117
Opc 14117
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Cat. No.: HY-165492
CAS No.: 103233-65-4
Target:  

Reactive Oxygen Species (ROS) NF-κB Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology

OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis .
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