103233-65-4
Chemical Structure
Opc 14117
- CAS No.: 103233-65-4
- Formula:C26H35N3O3
- Molecular Weight:437.57
InChIKey: LYAUICDWKQJAGX-UHFFFAOYSA-N
SMILES: OC1=C2C(CC(C)(C2NC(CN3CCN(CC3)C4=CC(OC)=CC=C4)=O)C)=C(C=C1C)C
Biological Activity: OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].
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Opc 14117 | OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis. | |||||||||||||||||||||
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- [1]. Nakai M, et al. Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum. Brain Res Mol Brain Res. 1999 Jan 22;64(1):59-68. [Content Brief]
- [2]. Aoyama N, et al. Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res. 2002 May 3;934(2):117-24. [Content Brief]
Keywords
