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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
DENV E
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "DENV E" in MCE Product Catalog:
Cat. No.: HY-N7781
CAS No.: 39025-24-6
Synonyms: (E)-Guggulsterone
Cat. No.: HY-N3942
CAS No.: 41983-91-9
Category:
Infection Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.
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Cat. No.: HY-136797
CAS No.: 1622060-51-8
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BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.
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Cat. No.: HY-P990817
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Cat. No.: HY-152082
CAS No.: 1809464-07-0
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DENV-IN-8 (Compound 5e) is a DENV2 inhibitor with an EC50 of 0.068 μM .
Cat. No.: HY-P991764
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Cat. No.: HY-P991769
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Cat. No.: HY-161808
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DENV ligand 2 is the ligand for DENV E protein.DENV ligand 2 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806). DENV ligand 2 is the active form of DENV ligand 1 (HY-161807) .
Cat. No.: HY-161807
CAS No.: 1628758-48-4
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DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806) .
Cat. No.: HY-161804
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GNF-2-deg is a PROTAC degrader targeting the dengue virus envelope protein (DENV E protein), with a DC50 of 0.83 μM in Huh7.5 cells. GNF-2-deg induces CRBN- and proteasome-dependent proteolysis of intracellular E protein. GNF-2-deg inhibits E protein-mediated membrane fusion and blocks viral particle production. GNF-2-deg reduces viral yield in infected cells and retains activity against E protein βOG pocket mutant virus-like particles (VLP). GNF-2-deg can be used in the research of dengue virus infection, Zika virus infection, Japanese encephalitis, West Nile virus infection and yellow fever .
Cat. No.: HY-176433
CAS No.: 79514-43-5
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NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .
Cat. No.: HY-161806
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ZXH-8-004 is a DENV E PROTAC degrader with a DC50 value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection .
Cat. No.: HY-144736
CAS No.: 2910757-30-9
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NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively .
Cat. No.: HY-N7781R
CAS No.: 39025-24-6
Synonyms: (E)-Guggulsterone (Standard)
Cat. No.: HY-P74197
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: E Protein; DENV; Envelope; Dengue virus (DENV) (type 1, strain US/Hawaii/1944) E/Envelope Protein Domain III
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Cat. No.: HY-P74190
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: E Protein; DENV; Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / Envelope Protein (ECD, His Tag)
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Cat. No.: HY-P704230
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Genome polyprotein; Protein prM; Peptide pr; Small envelope protein M; Matrix protein; Envelope protein E; Envelope Protein/E Protein (DENV); LGenome polyprotein; L
Cat. No.: HY-P74194
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: E Protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope Protein (ECD, His Tag)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
