country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161806

Copy Link Print Information

ZXH-8-004

ZXH-8-004 is a DENV E PROTAC degrader with a DC₅₀ value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection.
(Pink: Dengue Virus ligand (HY-161807); Blue: Cereblon ligand (HY-103596); Black: linker (HY-42149)).

For research use only. We do not sell to patients.

Formula: C₃₈H₃₃F₆N₇O₁₀
Molecular Weight:861.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ZXH-8-004 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ZXH-8-004 is a DENV E PROTAC degrader with a DC₅₀ value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection^[1]. (Pink: Dengue Virus ligand (HY-161807); Blue: Cereblon ligand (HY-103596); Black: linker (HY-42149)).

All PROTACs Isoforms :

In Vitro

ZXH-8-004 (2-12-2-deg) (0.07-20 μM; 24 h) induces CRBN- and proteasome-dependent depletion of intracellular DENV2 E protein in infected wild-type Huh7.5 cells, with a DC₅₀ of 0.21 μM and a maximum depletion rate of up to 95%^[1].
ZXH-8-004 (0.01-100 μM; 24 h) exerts CRBN-dependent enhanced anti-DENV2 activity in wild-type Huh7.5 cells, with an EC₉₀ of 1.67 μM^[1].
ZXH-8-004 (2-12-2-deg) (0.01-100 μM; 24 h) exhibits broad-spectrum and enhanced antiviral activity against ZIKV, JEV, WNV-Kunjin and YFV in Huh7.5 cells, with EC₉₀ values ranging from 4.77 μM to 22.14 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Infected wild-type Huh7.5 cells
Concentration:

0.07, 0.15, 0.3, 0.6, 1.2, 2.5, 5, 10, 20 μM
Incubation Time:

24 h
Result:

Induced CRBN- and proteasome-dependent depletion of intracellular DENV2 E protein.

Chemical Information

Molecular Weight 861.70
Formula C₃₈H₃₃F₆N₇O₁₀
SMILES

FC(F)(F)OC1=CC=C(NC2=CC=NC(NC3=CC=C(C(NCCOCCOCCOC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=O)C=C3OC(F)(F)F)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu HY, et al. Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications. 2024 Jun 19;15(1):5179. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

ZXH-8-004

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZXH-8-004 Related Classifications

HY-161806 Related Classifications