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Dipeptidase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dipeptidyl Peptidase (1) Drug Intermediate (1) SARS-CoV (1)
By Research Areas:	Endocrinology (1) Infection (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4559

H-Pro-Met-OH	Dipeptidyl Peptidase Drug Intermediate	Others
H-Pro-Met-OH is a dipeptide containing proline and methionine. H-Pro-Met-OH also serves as a substrate for prolinase and prolyl dipeptidase .

HY-P11879

LSALT peptide	SARS-CoV	Infection Inflammation/Immunology Endocrinology
LSALT peptide is a selective *DPEP-1* inhibitor with selectivity over DPEP2/3. LSALT peptide inhibits neutrophil and monocyte/macrophage recruitment, inflammation, and tissue injury. LSALT peptide reduces kidney damage, improves survival in murine sepsis and endotoxemia models. LSALT peptide can be used for the research of COVID-19, sepsis, acute respiratory distress syndrome, and acute kidney injury ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P4559

H-Pro-Met-OH	Dipeptidyl Peptidase Drug Intermediate	Others
H-Pro-Met-OH is a dipeptide containing proline and methionine. H-Pro-Met-OH also serves as a substrate for prolinase and prolyl dipeptidase .

HY-P11879

LSALT peptide	SARS-CoV	Infection Inflammation/Immunology Endocrinology
LSALT peptide is a selective *DPEP-1* inhibitor with selectivity over DPEP2/3. LSALT peptide inhibits neutrophil and monocyte/macrophage recruitment, inflammation, and tissue injury. LSALT peptide reduces kidney damage, improves survival in murine sepsis and endotoxemia models. LSALT peptide can be used for the research of COVID-19, sepsis, acute respiratory distress syndrome, and acute kidney injury ^[1] .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70003

	DPEP1 Protein, Human (HEK293, His) rHuDipeptidase 1/DPEP1, His; Dipeptidase 1; Dehydropeptidase-I; Microsomal Dipeptidase; Renal Dipeptidase; hRDP; DPEP1; MDP; RDP	Human	HEK293
	Dipeptidase 1 (DPEP1) has multiple enzymatic functions and can hydrolyze various dipeptides, including the conversion of leukotriene D4 to leukotriene E4. It is also involved in the degradation of cysteinylbisglycine resulting from the breakdown of glutathione. DPEP1 Protein, Human (HEK293, His) is the recombinant human-derived DPEP1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7740

	*Carnosine Dipeptidase 1/CNDP1 Protein, Human (HEK293, His)* rHuCarnosine Dipeptidase 1, His; Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Carnosine Dipeptidase 1; Glutamate Carboxypeptidase-Like Protein 2; Serum Carnosinase; CNDP1; CN1; CPGL2	Human	HEK293
	Carnosine Dipeptidase 1 Protein, Human (HEK293, His) is a human carnosine dipeptidase 1 protein with a his-flag, expressed in HEK293 cells. Carnosine Dipeptidase 1 is a member of the M20 metalloprotease family, encoded by the CNDP1 gene.

HY-P76272

	CNDP1 Protein, Mouse (HEK293, His) Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Cn1	Mouse	HEK293
	The CNDP1 protein is critical in cellular processes and catalyzes the hydrolysis of the Xaa-His dipeptide, with the highest activity against carnosine and anserine. This enzyme specificity highlights the critical role of CNDP1 in regulating the breakdown of specific dipeptides, especially those involving histidine. CNDP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CNDP1 protein, expressed by HEK293 , with C-His labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1)
Application:	IHC-P (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81486

	DPEP1/MDP Antibody (YA1231) DPEP1; MDP; RDP; Dipeptidase 1; Dehydropeptidase-I; Microsomal Dipeptidase; Renal Dipeptidase	IHC-P	Human
	DPEP1/MDP Antibody (YA1231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

HY-P81486A

	DPEP1/MDP Antibody (YA1231)(PBS only) DPEP1; MDP; RDP; Dipeptidase 1; Dehydropeptidase-I; Microsomal Dipeptidase; Renal Dipeptidase	IHC-P	Human
	DPEP1/MDP Antibody (YA1231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

HY-P81557

	DPEP1/MDP Antibody (YA1302) Dipeptidase 1, hRDP, MDP, RDP	IHC-P	Human, Rat
	DPEP1/MDP Antibody (YA1302) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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