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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
ENO1
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "ENO1" in MCE Product Catalog:
4
4 Cited Publications
Research Areas:
POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor [1].
1
1 Cited Publications
Synonyms: N-omega-Propyl-L-arginine
Target:
Research Areas:
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) .
1
1 Cited Publications
Synonyms: N-omega-Propyl-L-arginine hydrochloride
Target:
Research Areas:
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) .
Category:
Target:
Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors [1] .
Target:
Research Areas:
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects [1] .
Cat. No.: HY-RS16574
Target:
Research Areas:
Eno1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eno1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-117778B
Purity: ≥98.0%
Target:
SF2312 ammonium is a phosphonate Antibiotic and Enolase inhibitor, with an IC50 of 18.4 nM against E. coli enolase. SF2312 ammonium reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 ammonium exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 ammonium shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 ammonium can be used in research related to bacterial infections and gliomas [1] .
Cat. No.: HY-179578
CAS No.: 1262219-89-5
SU212 is a podophyllotoxin-derived ENO1 inhibitor and AMPK activator. SU212 can selectively induce oxidative phosphorylation, reduce glycolysis activity and glucose uptake in tumor cells, and directly bind to ENO1 without affecting these pathways in normal cells. SU212 induces apoptosis and promotes ENO1 degradation via proteasomal and autophagic pathways without inhibiting the catalytic activity. SU212 leads to mitotic arrest and apoptosis in TNBC (triple-negative breast cancer) cells by activating AMPK, demonstrating potent anti-tumor activity in vitro. SU212 inhibits tumor growth and metastasis in syngeneic, xenograft, and diabetic mouse models, exhibiting an excellent safety profile. SU212 can be used in research on t TNBC, diabetes, and fatty liver disease [1] .
Cat. No.: HY-RS04378
Target:
Research Areas:
ENO1 Human Pre-designed siRNA Set A contains three designed siRNAs for ENO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23007
Target:
Research Areas:
Eno1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Eno1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P991972
Cat. No.: HY-P991973
Cat. No.: HY-P70260A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuAlpha-ENOlase, His; Alpha-ENOlase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; ENOlase
1; MBP-1; MPB-1; Non-neural ENOlase; NNE; Phosphopyruvate hydratase; Plasminogen-binding
protein; ENO1
Cat. No.: HY-P70260
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuAlpha-ENOlase, His; Alpha-ENOlase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; ENOlase
1; MBP-1; MPB-1; Non-neural ENOlase; NNE; Phosphopyruvate hydratase; Plasminogen-binding
protein; ENO1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
