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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ER degrader11
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ER degrader11" in MCE Product Catalog:
Cat. No.: HY-176486
CAS No.: 2770911-29-8
Target:
Research Areas:
ER degrader 11 (Compound 5) is an orally active, brain-penetrant and selective estrogen receptor (ER) degrader (ERα IC50=1.6 nM). ER degrader 11 is promising for research of breast cancer brain metastasis .
Cat. No.: HY-168101
CAS No.: 3052336-87-2
Target:
Research Areas:
ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells .
Cat. No.: HY-168270
CAS No.: 2846112-04-5
Target:
Research Areas:
PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC50 of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research .
Cat. No.: HY-174870
Research Areas:
PROTAC ERα Degrader-11 is a selective and intrinsically fluorescent (Ex: 366 nm, Em: 440 nm) ERα PROTAC degrader. PROTAC ERα Degrader-11 shows good antiproliferative activity, selective ERα degradation and imaging capabilities in MCF-7 breast cancer cell lines. PROTAC ERα Degrader-11 induces G2/M phase arrest and induces apoptosis in MCF-7 cells. PROTAC ERα Degrader-11 is well-tolerated up to a dose of 500 mg/ kg with no acute toxicity in athymic nude mice. PROTAC ERα Degrader-11 can be used for the study of breast cancer.(Pink: ERα ligand (HY-167701), Blue: CRBN Ligand (HY-150831), Black: Linker, E3 ligase ligand-linker conjugate (HY-174880)) .
Cat. No.: HY-168271
Research Areas:
ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270) .
Cat. No.: HY-174880
CAS No.: 2407829-84-7
Research Areas:
CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand (HY-150831) and a linker. CRBN ligand-8-O-C6-NH2 can be used for synthesis of PROTAC ERα Degrader-11 (HY-174870) .
Cat. No.: HY-168272
CAS No.: 2520107-24-6
Research Areas:
(3S)Lenalidomide-piperazine-C-piperidine is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). (3S)Lenalidomide-piperazine-C-piperidine can be used to synthesize PROTAC PROTAC ER Degrader-11 (HY-168270) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
