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Cat. No.: HY-168270

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PROTAC ER Degrader-11

PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC₅₀ of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research.
(Pink: Estrogen Receptor/ERR ligand (HY-168271); Blue: Cereblon ligand (HY-W797329); Black: linker (HY-W262798)).

For research use only. We do not sell to patients.

CAS No.: 2846112-04-5
Formula: C₄₃H₅₃N₅O₄
Molecular Weight:703.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC ER Degrader-11 Chemical Structure

CAS No.: 2846112-04-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC₅₀ of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research^[1]. (Pink: Estrogen Receptor/ERR ligand (HY-168271); Blue: Cereblon ligand (HY-W797329); Black: linker (HY-W262798)).

IC₅₀ & Target^[1]

Cereblon

All PROTACs Isoforms :

All Estrogen Receptor/ERR Isoforms :

Chemical Information

CAS No. 2846112-04-5
Molecular Weight 703.91
Formula C₄₃H₅₃N₅O₄
SMILES

CC(C)C[C@@H]1[C@H](C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)C=C2)C8=CC=C(O)C=C8CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiangsu Hengrui Pharmaceuticals Co., Ltd, et al. Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine. World Intellectual Property Organization, WO2022206737 A1 2022-10-06

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PROTAC ER Degrader-11

All PROTACs Isoforms

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC ER Degrader-11 Related Classifications

HY-168270 Related Classifications