1 Result for "

Ethyl 3,4-dihydroxybenzoate (Standard)

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1 Results for "Ethyl 3,4-dihydroxybenzoate (Standard)" in MCE Product Catalog:

Ethyl 3,4-dihydroxybenzoate (Standard)
Ethyl 3,4-dihydroxybenzoate (Standard)
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Cat. No.: HY-W016409R
CAS No.: 3943-89-3
Synonyms: Protocatechuic acid Ethyl ester (Standard)
Category:  

Arachis hypogaea L. Leguminosae Phenols Polyphenols Plants

Target:  

Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis

Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .
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